An exploratory mixed-methods questionnaire study investigating motivators for and reservations about clinical research participation in people living with HIV.
Clinical research in healthcare settings offers substantial benefits, including reduced mortality rates in research-active hospitals and access to novel treatments for participants. Despite these advantages, research often faces recruitment challenges, particularly under-representation of women and...
| Publicado en: | AIDS Care Vol. 37; no. 12; pp. 2161 - 2174 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Dec2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189730461&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189730461 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09540121 AAE jtl: AIDS Care issn: 09540121 maglogo: N pubinfo: dt: Dec2025 vid: 37 iid: 12 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 189730461 186771042 189730461 189730461 10.1080/09540121.2025.2534531 189730461 ppf: 2161 ppct: 13 formats: tig: atl: An exploratory mixed-methods questionnaire study investigating motivators for and reservations about clinical research participation in people living with HIV. aug: au: Petersen, Claire Wood, M. Dransfield, F. Grundy-Bowers, M. Clunie, G. Winston, A. affil: Clinical Trials Centre, Imperial College Healthcare NHS Trust, London, UK sug: subj: Motivation Patient Attitudes Clinical Research HIV-Positive Persons Research Subject Recruitment Evaluation Human Exploratory Research Multimethod Studies Ambulatory Care Facilities United Kingdom Information Resources Decision Making, Patient Health Knowledge Altruism Health Services Accessibility Communication Health Personnel Male Female Time Commitment Caring Accountability Professional-Patient Relations Flexible Scheduling Appointments and Schedules Descriptive Statistics Purposive Sample Convenience Sample Confidence Intervals Adult Middle Age Aged Questionnaires Models, Theoretical Structured Questionnaires Social Behavior Adverse Health Care Event Emotions Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Clinical research in healthcare settings offers substantial benefits, including reduced mortality rates in research-active hospitals and access to novel treatments for participants. Despite these advantages, research often faces recruitment challenges, particularly under-representation of women and ethnic minorities. This study explores the views of people living with HIV regarding research participation. This mixed-methods study was conducted at a central London hospital's HIV outpatient clinic and Clinical Trials Centre from April 2018 to January 2019. Using the COM-B models as a theoretical framework, questionnaires were designed for individuals currently or previously involved in research, and for those with no prior research involvement. Questions included demographics, motivators and reservations about research participation, and the importance of information sources when deciding to participate in research. Quantitative data were analysed descriptively, and a framework analysis of qualitative data was completed. Of the 155 respondents, 50 were participating in research, and 105 were not. Key motivators included advancing medical knowledge, altruism and access to new treatments. Major barriers were time commitments and concerns about side effects. 80% of people participating in research, and 74% of those not participating rating rated discussions with regular clinicians to be very important when deciding to participate in research. Women faced similar barriers to the overall cohort, particularly related to time commitments and care-giving responsibilities. Research participation is influenced by the therapeutic relationship with, and input from regular clinicians. Addressing barriers such as time commitments through flexible scheduling, integrating research and clinical visits, and utilising remote visits could improve recruitment. Involving patients in research design via Patient and Public Involvement and Engagement (PPIE) ensures protocols are acceptable and tailored to participant needs. Effective collaboration between researchers and clinicians is essential to optimise research recruitment. Clear, empathetic communication and flexible study designs can address participant concerns, ultimately enhancing involvement in clinical research. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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