Network toxicology and molecular docking techniques to explore the mechanism of bisphenol A on obesity.
The study investigates how bisphenol A (BPA) exposure may lead to obesity (OB) by identifying molecular mechanisms and suggests a new research approach for examining the health effects of chemical toxins. Researchers identified 237 potential targets associated with BPA exposure and OB using CTD, STI...
| Publicado en: | International Journal of Environmental Health Research Vol. 35; no. 12; pp. 3700 - 3713 |
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| Autores principales: | , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Dec2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189730986&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189730986 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09603123 57L jtl: International Journal of Environmental Health Research issn: 09603123 maglogo: Y pubinfo: dt: Dec2025 vid: 35 iid: 12 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 189730986 184592354 189730986 189730986 10.1080/09603123.2025.2494735 189730986 ppf: 3700 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Network toxicology and molecular docking techniques to explore the mechanism of bisphenol A on obesity. aug: au: Lingjuan, Yang Yu, Huang Lei, Zhang affil: Innovation Management and High-tech Service center, Productivity Centre of Jiangsu Province, Nanjing, Jiangsu, China sug: subj: Molecular Docking Simulation Phenols Adverse Effects Environmental Pollutants Adverse Effects Endocrine Disruptors Adverse Effects Obesity Risk Factors Toxins Toxicology Human Interleukins PPAR-gamma Agonists Phosphotransferases Signal Transduction Environmental Exposure Adverse Effects Insulin Metabolism Insulin Resistance Cell Death Growth Inhibitors Inflammation Risk Assessment ab: The study investigates how bisphenol A (BPA) exposure may lead to obesity (OB) by identifying molecular mechanisms and suggests a new research approach for examining the health effects of chemical toxins. Researchers identified 237 potential targets associated with BPA exposure and OB using CTD, STITCH, DrugBank, GeneCards, and OMIM databases. Analysis with STRING and Cytoscape revealed 10 key targets, including INS, IL-6, AKT1, and PPARG. Enrichment analysis via the DAVID database indicated that these targets are primarily involved in PI3K-Akt and Insulin signaling pathways. These findings indicate that BPA may contribute to the occurrence and development of OB by influencing apoptosis, proliferation, inflammatory signaling, and insulin resistance. Molecular docking showed strong binding of BPA to INS, IL-6, AKT1, and PPARG, with molecular dynamics simulations revealing a stable complex of BPA and PPARG. This study offers insights into BPA's role in OB and supports efforts to prevent and treat OB diseases linked to exposure to BPA-containing plastic products and certain BPA-inundated environments. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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