Chronic pain prevalence and severity in females before & after menopause versus males in a large multi-center database.
Aims This observational study aimed to explore the prevalence and severity of chronic pain in menopausal-aged females. Materials & Methods We identified participants in the NIH-sponsored All of Us database with a diagnosis of chronic pain. We examined the severity of pain based on numeric rating sca...
| Publicado en: | Pain Management Vol. 15; no. 12; pp. 915 - 921 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Dec2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189732862&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189732862 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17581869 B9ZX jtl: Pain Management issn: 17581869 maglogo: N pubinfo: dt: Dec2025 vid: 15 iid: 12 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 189732862 189732862 189732862 10.1080/17581869.2025.2561399 189732862 ppf: 915 ppct: 6 formats: tig: atl: Chronic pain prevalence and severity in females before & after menopause versus males in a large multi-center database. aug: au: Ricker, Adam Farley, Nicole McClure, Jesse J. Goudman, Lisa Berwal, Deepak Khazen, Olga Telkes, Ilknur Hani Abdullah, Umm E Wilson, Candy Pilitsis, Julie G. affil: Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA sug: subj: Databases, Health Evaluation Chronic Pain Risk Factors Risk Assessment Severity of Illness Evaluation Menopause Physiology Sex Factors Evaluation Human Male Female Adolescence Adult Middle Age Multicenter Studies Prevalence Pain Measurement Nonexperimental Studies Age Factors United States Scales Race Factors Ethnic Groups Complex Regional Pain Syndromes Physiopathology Fibromyalgia Physiopathology Postoperative Pain Physiopathology Analysis of Variance Post Hoc Analysis Descriptive Statistics Data Analysis Software Intermittent Claudication Physiopathology Migraine Physiopathology Back Pain Physiopathology Funding Source Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Aims This observational study aimed to explore the prevalence and severity of chronic pain in menopausal-aged females. Materials & Methods We identified participants in the NIH-sponsored All of Us database with a diagnosis of chronic pain. We examined the severity of pain based on numeric rating scale score (NRS). Among those with chronic pain, we generated four sub-cohorts: females ≥ 51 years old who were menopausal, females 18–50 years who were considered pre-menopausal, and age matched male cohorts. Results The 53,289 participants were separated into four cohorts by age and sex: females 18–50 (10,269), females ≥ 51 (20,182), males 18–50 (4,989), and males ≥ 51 (17,849). Both older females and older males had lower pain levels than the sex-matched 18–50 group (p < 0.001). Findings were consistent in White, Black, and non-Hispanic cohorts. When comparing older adults, females ≥ 51 had higher pain levels than males ≥ 51 (p < 0.001). Conclusions We found that independent of sex, NRS scores were lower in older adults compared to younger cohorts. Older women however had more pain than their male counterparts. These findings have implications for the design of patient-tailored therapeutic treatments and warrant further exploration of physiological and psychosocial causes. Plain Language Summary Chronic pain is a major health concern that affects millions of people and interferes with everyday life. Women often report pain more than men and this may be related to hormones as they age, especially around menopause. In this study, we identified participants in a large, diverse national database with a diagnosis of chronic pain to see how age and menopause affect pain levels. We compared 4 groups: older women who were menopausal, younger women who were pre-menopausal, and men in the same age groups. We found that older adults reported less pain than younger adults. However, older women had higher pain scores than men of the same age. This was true across racial and ethnic groups. This may suggest that hormone changes in women may play a role in how pain levels. Understanding this difference can help create more personalized treatment plans. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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