Andrographolide increases adult hippocampal neurogenesis and prolongs contextual fear memory.
Rationale: Adult neurogenesis in the brain enhances memory retention, particularly under conditions of compromised hippocampal function. However, it is unclear whether changing neurogenesis levels would affect the longevity of a physiological memory trace. Objective: Here, we hypothesized that the m...
| Publicado en: | Psychopharmacology Vol. 242; no. 12; pp. 2769 - 2785 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Dec2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189750012&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189750012 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Dec2025 vid: 242 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 189750012 186192683 10.1007/s00213-025-06832-9 189750012 ppf: 2769 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Andrographolide increases adult hippocampal neurogenesis and prolongs contextual fear memory. aug: au: Jaimes, Laura F. Passos, Matheus C. Mansk, Lara M. Z. de Castro, Caio M. Vega, Julián T. F. de O. Guarnieri, Leonardo Mourão, Flávio A. G. Birbrair, Alexander Santos, Victor R. Moraes, Márcio F. D. Pereira, Grace S. affil: https://ror.org/0176yjw32 Núcleo de Neurociências, Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627– CEP, Campus Pampulha, 31270-901, Belo Horizonte, MG, Brazil sug: ab: Rationale: Adult neurogenesis in the brain enhances memory retention, particularly under conditions of compromised hippocampal function. However, it is unclear whether changing neurogenesis levels would affect the longevity of a physiological memory trace. Objective: Here, we hypothesized that the mechanisms of potentially pro-neurogenic treatments and the nature of the memory trace are determinant factors in defining whether memories persist. Methods: We subjected adult male C57Bl/6 mice to behavioral procedures that evoke fear memories, which naturally fade within 10 days. We then examined whether increasing adult neurogenesis could prevent the natural decay of these memories. We investigated the hippocampus's dependence on these memories using context, sound, or smell as the conditioned stimuli. Memantine (MEM), andrographolide (ANDRO), and an enriched environment (EE) were used to investigate their effects on neurogenesis and memory retention. Results: EE and ANDRO increased neurogenesis in the dentate gyrus of the hippocampus (DG). Interestingly, neither treatment altered the progenitor cell population in the DG of Nestin-GFP mice. To gain further insight into the effects of ANDRO and MEM, we recorded the oscillations in DG local field potentials (LFP) immediately and 7 days after the pharmacological treatments. Acute administration of MEM increased slow gamma power in DG, while ANDRO had the opposite effect. Finally, we tested whether treatments would extend the fear conditioning memory. ANDRO and EE increased fear memory, but only for contextual fear conditioning (CFC). Conclusions: Our study shows that different methods allegedly used to increase adult neurogenesis have varying effects on DG neurophysiology. Moreover, it suggests that memories reliant on the hippocampus, such as CFC, may be more prone to alterations in adult neurogenesis than memories less dependent on this brain region, such as auditory and olfactory conditioned fear memories. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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