Comparing safety, performance and user perceptions of a patient-specific indication-based prescribing tool with current practice: a mixed methods randomised user testing study.
Background Medication errors are the leading cause of preventable harm in healthcare. Despite proliferation of medication-related clinical decision support systems (CDSS), current systems have limitations. We therefore developed an indication-based prescribing tool. This performs dose calculations u...
| Publicado en: | BMJ Quality & Safety Vol. 34; no. 11; pp. 737 - 747 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
BMJ Publishing Group
Nov2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189751548&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189751548 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20445415 BFNQ jtl: BMJ Quality & Safety issn: 20445415 maglogo: N pubinfo: dt: Nov2025 vid: 34 iid: 11 pid: 8280 pub: BMJ Publishing Group artinfo: ui: 189751548 189751548 189751548 10.1136/bmjqs-2024-017733 189751548 ppf: 737 ppct: 10 formats: tig: atl: Comparing safety, performance and user perceptions of a patient-specific indication-based prescribing tool with current practice: a mixed methods randomised user testing study. aug: au: Feather, Calandra Clarke, Jonathan Appelbaum, Nicholas Darzi, Ara Franklin, Bryony Dean affil: Department of Surgery and Cancer, Imperial College London, London, UK sug: subj: Medication Errors Prevention and Control Dosage Forms Patient Safety Medication Errors Epidemiology Prescribing Patterns Workload Measurement Simulations Task Performance and Analysis Decision Support Systems, Clinical Workflow Feedback Human Randomized Controlled Trials Random Assignment Comparative Studies Multimethod Studies England Crossover Design Exploratory Research National Health Programs England Self Report Semi-Structured Interview Descriptive Statistics Odds Ratio Thematic Analysis Convenience Sample Questionnaires Confidence Intervals Multivariate Analysis Data Analysis Software Funding Source ab: Background Medication errors are the leading cause of preventable harm in healthcare. Despite proliferation of medication-related clinical decision support systems (CDSS), current systems have limitations. We therefore developed an indication-based prescribing tool. This performs dose calculations using an underlying formulary and provides patient-specific dosing recommendations. Objectives were to compare the incidence and types of erroneous medication orders, time to prescribe (TTP) and perceived workload using the NASA Task Load Index (TLX), in simulated prescribing tasks with and without this intervention. We also sought to identify the workflow steps most vulnerable to error and to gain participant feedback. Methods A simulated, randomised, cross-over exploratory study was conducted at a London NHS Trust. Participants completed five simulated prescribing tasks with, and five without, the intervention. Data collection methods comprised direct observation of prescribing tasks, self-reported task load and semistructured interviews. A concurrent triangulation design combined quantitative and qualitative data. Results 24 participants completed a total of 240 medication orders. The intervention was associated with fewer prescribing errors (6.6% of 120 orders) compared with standard practice (28.3% of 120 orders; odds ratio 0.18, p<0.01), a shorter TTP and lower overall NASA-TLX scores (p<0.01). Control arm workflow vulnerabilities included failures in identifying correct doses, applying maximum dose limits and calculating patient-specific dosages. Intervention arm errors primarily stemmed from misidentifying patient-specific information from the medication scenario. Thematic analysis of participant interviews identified six themes: navigating trust and familiarity, addressing challenges and suggestions for improvement, integration of local guidelines and existing CDSS, intervention endorsement, 'search by indication' and targeting specific patient and staff groups. Conclusion The intervention represents a promising advancement in medication safety, with implications for enhancing patient safety and efficiency. Further real-world evaluation and development of the system to meet the needs of more diverse patient groups, users and healthcare settings is now required. Trial registration number NCT05493072. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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