Machine Learning–Based Enhanced MRI Radiomics for PDCD1 Prognostication and Expression Prediction in Breast Cancer.
Background: Programmed cell death 1 (PDCD1) is an immune checkpoint inhibitor that plays an important role in immune evasion in breast cancer (BC). In this study, we aimed to evaluate the correlation between PDCD1 expression, immune cell tumor infiltration, and prognosis. In addition, we also develo...
| Publicado en: | Clinical Medicine Insights: Oncology Vol. 19; pp. 1 - 11 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
11/28/2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189855970&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189855970 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11795549 B3KT jtl: Clinical Medicine Insights: Oncology issn: 11795549 maglogo: Y pubinfo: dt: 11/28/2025 vid: 19 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 189855970 189855970 189855970 10.1177/11795549251399383 189855970 ppf: 1 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Machine Learning–Based Enhanced MRI Radiomics for PDCD1 Prognostication and Expression Prediction in Breast Cancer. aug: au: Gao, Yingying Li, Zihan Li, Ziyun Gao, Xueyan affil: The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, P.R. China sug: subj: Breast Neoplasms Familial and Genetic Breast Neoplasms Prognosis Magnetic Resonance Imaging Methods Radiomics Programmed Cell Death Protein 1 Receptor Gene Expression Prediction Models Evaluation Machine Learning Algorithms Evaluation Tumor Markers, Biological Human Breast Neoplasms Immunology Neoplasm Invasiveness Survival Analysis Overall Survival Validity Descriptive Statistics Confidence Intervals Univariate Statistics Signal Transduction Killer Cells, Natural Tumor Necrosis Factor Interleukins STAT Proteins NF-kappa B Interferons RNA Sequence Analysis Support Vector Machine ROC Curve Regression Calibration Data Analysis Software ab: Background: Programmed cell death 1 (PDCD1) is an immune checkpoint inhibitor that plays an important role in immune evasion in breast cancer (BC). In this study, we aimed to evaluate the correlation between PDCD1 expression, immune cell tumor infiltration, and prognosis. In addition, we also developed a predictive model to determine PDCD1 expression levels in patients with BC based on radiomics features extracted from magnetic resonance imaging (MRI). Methods: Clinical data of 1082 patients with BC extracted from The Cancer Genome Atlas (TCGA) and MRI data of 108 patients with BC extracted from The Cancer Imaging Archive (TCIA) were used to determine the correlation between PDCD1 expression levels and the prognosis, clinical stage, survival, and levels of immune cell tumor infiltration in patients with BC. Predictive radiomics features for PDCD1 were extracted by 2 physicians from MRI data. The top 5 predictive features were evaluated and selected to build 2 machine learning models. Results: The PDCD1 expression levels were significantly higher in tumor tissues from patients with BC (P <.001). High PDCD1 expression levels were associated with improved overall survival, hazard ratio (HR) = 0.63, 95% confidence interval (CI) 0.425-0.934, P =.021. The PDCD1 expression levels showed a significant positive correlation with immune cell infiltration, including CD8 (P <.001) and Treg (P <.001). Both MRI radiomics models demonstrated good accuracy, strong clinical utility, and a high level of consistency in discriminating between low and high PDCD1 expression levels (P >.05). Conclusions: PDCD1 expression showed a good correlation with prognosis and tumor immune cell infiltration. The MRI radiomics model accurately predicted PDCD1 expression levels and could potentially serve as a noninvasive tool to predict early tumor response to immunotherapy. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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