Phenolic Compounds of Justicia gendarussa Show Pharmacological Potentials Against Pain, Oxidation, Hyperglycemia, Diarrhea, and Microbes: Phytopharmacological and Computational Approaches.
Background: Justicia gendarussa is a branched shrub spread across Indian, Sri Lankan, and Malaysian forests. It has been widely used across many countries to treat asthma, rheumatism, colics in children, eczema, and HIV. The study goal was to investigate the phytoconstituents from J. gendarussa and...
| Publicado en: | BioMed Research International Vol. 2025; pp. 1 - 21 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
12/9/2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189914071&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189914071 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 12/9/2025 vid: 2025 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 189914071 189914071 189914071 10.1155/bmri/2561508 189914071 ppf: 1 ppct: 20 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Phenolic Compounds of Justicia gendarussa Show Pharmacological Potentials Against Pain, Oxidation, Hyperglycemia, Diarrhea, and Microbes: Phytopharmacological and Computational Approaches. aug: au: Munny, Farzana Akter Islam, Mehedi Akter, Mahafuza Ferdousi, Mushtahsin Asif, Md. Moaz Ahmed Hossain, Md. Solaiman Sharmin, Sabrina Zahidul Islam, Md Hossain, Md. Aslam Islam, Md. Rabiul Banerjee, Baisakhi affil: Department of Pharmaceutical Chemistry,, Faculty of Pharmacy,, University of Dhaka,, Dhaka, Bangladesh, du.ac.bd sug: subj: Phenols Analysis Phenols Pharmacodynamics Pain Drug Therapy Oxidative Stress Drug Effects Hyperglycemia Drug Therapy Diarrhea Drug Therapy Microbial Contamination Prevention and Control Plants, Medicinal Therapeutic Use Plants, Medicinal Pharmacodynamics Plants, Medicinal Analysis Antioxidants Pharmacodynamics Antilipemic Agents Pharmacodynamics Antidiarrheals Pharmacodynamics Antiinfective Agents Pharmacodynamics Analgesics Pharmacodynamics Drug Efficacy Evaluation Plant Extracts Therapeutic Use Plant Extracts Pharmacodynamics Plant Extracts Analysis Animal Studies Molecular Structure Microbial Contamination Phytochemicals Therapeutic Use Phytochemicals Pharmacodynamics Bioinformatics Molecular Docking Simulation Mice Models, Biological Chromatography, Liquid Terpenes Pharmacodynamics Phytosterols Pharmacodynamics Glycerides Pharmacodynamics Magnetic Resonance Spectroscopy Free Radical Scavengers Drug Effects Antioxidants Administration and Dosage Antilipemic Agents Administration and Dosage Antidiarrheals Administration and Dosage Antiinfective Agents Administration and Dosage Analgesics Administration and Dosage Glutathione Drug Effects Receptors, Cell Surface Drug Effects Membrane Transport Proteins Drug Effects Cox-2 Inhibitors Drug Effects Oxidoreductases Drug Effects Plant Leaves Analysis Plant Leaves Pharmacodynamics In Vivo Studies In Vitro Studies Microbial Culture and Sensitivity Tests Dose-Response Relationship, Drug Computer Simulation Liquid Chromatography-Mass Spectrometry Hypoglycemic Agents Pharmacodynamics Gram-Positive Bacteria Drug Effects Gram-Negative Bacteria Drug Effects Fungi Drug Effects Glyburide Analysis Receptors, Opioid Drug Effects Descriptive Statistics Data Analysis Software Analysis of Variance ab: Background: Justicia gendarussa is a branched shrub spread across Indian, Sri Lankan, and Malaysian forests. It has been widely used across many countries to treat asthma, rheumatism, colics in children, eczema, and HIV. The study goal was to investigate the phytoconstituents from J. gendarussa and to discover its therapeutic potential against various disease conditions. Methods: The plant sample was collected, dried, and grinded into coarse powder which was then soaked in methanol for 2 weeks. After the maceration process, the crude methanolic extract was subjected to solvent–solvent partitioning into four different fractions: n‐hexane soluble fraction (HSF), dichloromethane soluble fraction (DMSF), ethyl acetate soluble fraction (EASF), and aqueous fraction (AQF). DMSF was chemically evaluated through chromatographic separation, and all the fractions including the crude methanolic extracts were assessed for their potential pharmacological activities against pain, oxidative stress, hyperglycemia, diarrhea, and microbes following standard protocols. Results: Chemical investigation results in the isolation of lupeol, β‐sitosterol, and 1‐monostearin. The structures of the compounds were elucidated through meticulous NMR spectroscopic analysis. In a DPPH free radical scavenging assay, prominent action was noticed by EASF, with a median inhibition concentration (IC50) of 24.207 g/mL in comparison to the BHT with an IC50 value of 23.159 g/mL. In central analgesic activity, all the results were highly significant, with the highest (233.47%) time elongation in comparison to the control, observed after 90 min at 600 mg/kg b.w. and maximum peripheral analgesic activity of 61.96% was found at a dose of 600 mg/kg b.w. Two test doses (600 and 400 mg/kg b.w.) demonstrated substantial hypoglycemic and antidiarrheal effects that became more pronounced over time. The isolated compounds demonstrated impressive binding scores when interacting with glutathione reductase (3GRS), mu‐opioid receptor (MOR), kappa opioid receptor (KOR), and glucose transporter 3 (GLUT 3) receptors. However, their performance was notably lacking in terms of binding with cyclooxygenase‐2 (COX‐2) and dihydrofolate reductase (DHFR) receptors. Conclusion: Three isolated phytochemicals demonstrate promising binding affinities with the receptor molecules that support the pharmacological findings of this study. However, additional research needs to be conducted to isolate more phytoconstituents and affirm the pharmacological potential of J. gendarussa. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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