Exploring the Potential Targets and Protective Agents in Mercury-Induced Anxiety Disorders Using Network Toxicology, Network Pharmacology, and Molecular Docking.
Studies show that anxiety is one of the most common symptoms of mercury poisoning. The mechanism of mercury toxicity is not known in detail. This study aimed to broaden our understanding of mercury-induced anxiety and suggest potential protective agents. A list of genes associated with anxiety was e...
| Publicado en: | Iranian Journal of Child Neurology Vol. 19; no. 4; pp. 1 - 15 |
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| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Iranian Journal of Child Neurology
Autumn2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189920102&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189920102 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17354668 A91T jtl: Iranian Journal of Child Neurology issn: 17354668 maglogo: N pubinfo: dt: Autumn2025 vid: 19 iid: 4 pid: 56766 pub: Iranian Journal of Child Neurology place: Tehran, <Blank> artinfo: ui: 189920102 189920102 189920102 10.22037/ijcn.v19i4.49672 189920102 ppf: 1 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Exploring the Potential Targets and Protective Agents in Mercury-Induced Anxiety Disorders Using Network Toxicology, Network Pharmacology, and Molecular Docking. aug: au: Farahani, Masoumeh Bagheri, Fatemeh Rezaei-Tavirani, Mostafa Fateminasab, Fatemeh affil: Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran sug: subj: Mercury Adverse Effects Anxiety Disorders Chemically Induced Network Pharmacology Toxicology Molecular Docking Simulation Human Exploratory Research Comparative Studies Molecular Structure Gene Expression Drug Effects Interleukins Inflammation Quercetin Pharmacodynamics Selenium Pharmacodynamics Curcumin Pharmacodynamics Glutathione Pharmacodynamics Anxiety Disorders Drug Therapy Quercetin Therapeutic Use Selenium Therapeutic Use Molecular Biology ab: Studies show that anxiety is one of the most common symptoms of mercury poisoning. The mechanism of mercury toxicity is not known in detail. This study aimed to broaden our understanding of mercury-induced anxiety and suggest potential protective agents. A list of genes associated with anxiety was extracted from the overlap between GeneCards, DisGeNET, and Diseases to decipher protein-protein interaction (PPI) and core subnetwork. The comparative toxicogenomic database (CTD) helped to identify core mercury targets in anxiety disorders. Detailed interactions and relevant functions were obtained through GeneMANIA. Network pharmacology and molecular docking approaches identified potential protective agents-mercury target interactions. Among the eight proteins in the anxiety-related core sub-network (IL1B, IL6, TNF, IFNG, STAT3, TP53, EP300, and ESR1), the top-ranked proteins IL1B, IL6, TNF, and IFNG were revealed as core mercury targets with key interactions in disrupting the inflammatory responses and interfering with cellular processes. GeneMANIA highlighted the functions of CASP1, TNFAIP3, and SQSTM1 as first neighbors of the core mercury targets. Quercetin, selenium, curcumin, and glutathione were specified as factors that target the most mercuryresponsive genes. Molecular docking revealed strong binding affinities between protective agents (quercetin and curcumin) and core target proteins. This study presented a network biology approach in toxicology and pharmacology to further understand the mechanism of mercury toxicity and its therapeutic solution for anxiety disorders. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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