Differences in Clinical Trial Availability vs Distribution of Disease Among Gynecological Cancers.
Objective: Given disparities in incidence and outcomes among racial and ethnic groups, and differences in patient characteristics among the 3 main types of gynecologic cancer, we examined whether clinical trial availability at a large, high-enrolling National Cancer Institute-designated Comprehensiv...
| Publicado en: | Oncology (08909091) Vol. 39; no. 10; pp. 456 - 463 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
MJH Life Sciences
Nov/Dec2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189929348&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189929348 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08909091 YYT jtl: Oncology (08909091) issn: 08909091 maglogo: N pubinfo: dt: Nov/Dec2025 vid: 39 iid: 10 pid: 54670 pub: MJH Life Sciences place: Cranbury, New Jersey artinfo: ui: 189929348 189929348 189929348 10.46883/2025.25921058 189929348 ppf: 456 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Differences in Clinical Trial Availability vs Distribution of Disease Among Gynecological Cancers. aug: au: Nañez, Andrea I. Velez, Maria A. Zakhour, Mae Garon, Edward B. affil: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of California, San Francisco, CA sug: subj: Ovarian Neoplasms Ethnology Uterine Neoplasms Ethnology Cervix Neoplasms Ethnology Clinical Trials Research Subject Recruitment Ethnic Groups Race Factors Cancer Care Facilities California Human Female Cancer Patients California Retrospective Design Record Review Prospective Studies Comparative Studies Descriptive Statistics Data Analysis Software Chi Square Test Fisher's Exact Test Academic Medical Centers Sociodemographic Factors Healthcare Disparities Health Services Accessibility Ovarian Neoplasms Classification Uterine Neoplasms Classification Cervix Neoplasms Classification Female ab: Objective: Given disparities in incidence and outcomes among racial and ethnic groups, and differences in patient characteristics among the 3 main types of gynecologic cancer, we examined whether clinical trial availability at a large, high-enrolling National Cancer Institute-designated Comprehensive Cancer Center reflects the clinical volume of each cancer in the catchment area. We also assessed whether the patients who consented to the trials reflected the racial and ethnic distribution of each cancer type. Methods: Patients who consented to ovarian, uterine, and cervical cancer clinical trials at the UCLA Jonsson Comprehensive Cancer Center in Los Angeles, California, from 2013 through 2018 were included. Clinical trial and patient-level data were collected. Los Angeles County cancer incidence data were used to represent disease burden in the catchment area. χ-Square and Fisher exact tests were used to compare proportions. Results: Twenty-four gynecologic oncology clinical trials were identified: 16 (67%) ovarian, 5 (21%) uterine, and 3 (12%) cervical cancer trials. Compared with corresponding county incidence rates, respectively, the proportion of patients with ovarian (82% vs 25%), uterine (9% vs 59%), or cervical (9% vs 6%) cancer who consented for clinical trials differed significantly (P < .001). The racial/ethnic distribution of patients also differed for ovarian (P < .001) and cervical cancer trials (P = .005). Patients who were Black or Asian were underrepresented in ovarian and cervical cancer trials; Hispanic patients were underrepresented in ovarian trials. Conclusions: The distribution of clinical trials and patients who consented did not reflect the incidence or racial and ethnic makeup of gynecologic cancers in the catchment area. Greater efforts are needed to align trial availability and enrollment with disease burden and population diversity. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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