Prevalence and Correlates of Depression and Bipolar Disorder Among Patients Maintained on Methadone and Buprenorphine in Ukraine.

Psychiatric and substance use disorders frequently coexist and require co-management, yet little is known about the prevalence of psychiatric disorders among patients maintained on medications for opioid use disorder (MOUD) in Ukraine. We analyzed baseline data from a cluster-randomized trial of an...

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Publicado en:International Journal of Mental Health & Addiction Vol. 23; no. 6; pp. 4310 - 4328
Autores principales: Morozova, Olga, Dvoriak, Vira, Dumchev, Kostyantyn, Machavariani, Eteri, Bromberg, Daniel J., Dvoriak, Sergii, Altice, Frederick L.
Formato: Artículo
Publicado: Springer Nature Dec2025
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Acceso en línea:Ver este registro en EBSCOhost
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      dt: Dec2025
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      pub: Springer Nature
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        10.1007/s11469-024-01353-6
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        atl: Prevalence and Correlates of Depression and Bipolar Disorder Among Patients Maintained on Methadone and Buprenorphine in Ukraine.
      aug:
        au:
          Morozova, Olga
          Dvoriak, Vira
          Dumchev, Kostyantyn
          Machavariani, Eteri
          Bromberg, Daniel J.
          Dvoriak, Sergii
          Altice, Frederick L.
        affil:
          https://ror.org/024mw5h28 Department of Public Health Sciences, University of Chicago, 5841 S Maryland Ave, 60637, Chicago, IL, USA
          https://ror.org/02jtzez66 Ukrainian Institute On Public Health Policy, Kyiv, Ukraine
          https://ror.org/03v76x132 Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA
          https://ror.org/03v76x132 Center for Interdisciplinary Research On AIDS, Yale University, New Haven, CT, USA
          https://ror.org/03v76x132 Division of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA
      su:
        Ukraine
        Mental depression
        Bipolar disorder
        Methadone treatment programs
        Integrated health care delivery
        Comorbidity
        Ukrainians
        Buprenorphine
        Opioid abuse
      sug:
        subj:
          Mental depression
          Bipolar disorder
          Methadone treatment programs
          Ukraine
          Integrated health care delivery
          Comorbidity
          Ukrainians
          Buprenorphine
          Opioid abuse
      keyword:
        Eastern Europe
        Integrated care
        Medical and Health Sciences Clinical Sciences Public Health and Health Services
        Medications for opioid use disorder (MOUD)
        Mental health
        Opioid agonist treatment (OAT)
        Psychiatric disorders
        Eastern Europe
        Integrated care
        Medical and Health Sciences Clinical Sciences Public Health and Health Services
        Medications for opioid use disorder (MOUD)
        Mental health
        Opioid agonist treatment (OAT)
        Psychiatric disorders
      ab: Psychiatric and substance use disorders frequently coexist and require co-management, yet little is known about the prevalence of psychiatric disorders among patients maintained on medications for opioid use disorder (MOUD) in Ukraine. We analyzed baseline data from a cluster-randomized trial of an integrated model of depression diagnosis and treatment among MOUD patients in Ukraine to determine prevalence and correlates of depression and bipolar disorder in this population. From a randomly selected sample of 1345 patients on MOUD at 12 sites in Ukraine, screening for moderate/severe depression (PHQ-9) and bipolar disorder (MDQ) yielded high prevalence of 50% (95% CI 42–58%) and 12% (95% CI 8–16%), respectively. Correlates of depression included recent drug injection, worse physical health, shorter duration on MOUD, higher methadone dosages, and stigma levels, being unmarried and having low trust in physicians. Bipolar disorder was correlated with alcohol use disorder and prior incarceration. The high burden of mental health disorders among patients prescribed MOUD in Ukraine calls for the urgent implementation of models to address co-occurring disorders, including those using integrated care strategies.
      pubtype: Academic Journal
      doctype: Article
      src: R
    language: English
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