Non‐Endocardial Radiofrequency Ablation of Premature Ventricular Complexes (NERA‐PVC): Safety, Efficacy and Outcome.
Background: Radiofrequency (RF) ablation of premature ventricular complexes (PVCs) is a well‐established treatment for patients high PVCs burden, even when arising from epicardial/intramural localization. Consistent data about safety of using high power RF is lacking in the literature in these regio...
| Published in: | Journal of Cardiovascular Electrophysiology Vol. 36; no. 12; pp. 3126 - 3136 |
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| Main Authors: | , , , , , , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
Dec2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=190212323&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 190212323 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10453873 GSB jtl: Journal of Cardiovascular Electrophysiology issn: 10453873 maglogo: Y pubinfo: dt: Dec2025 vid: 36 iid: 12 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 190212323 185618278 190212323 190212323 10.1111/jce.16716 190212323 ppf: 3126 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Non‐Endocardial Radiofrequency Ablation of Premature Ventricular Complexes (NERA‐PVC): Safety, Efficacy and Outcome. aug: au: Falzone, Pasquale Valerio Vazquez‐Calvo, Sara Guichard, Jean Baptiste Althoff, Till Garre, Paz Tolosana, Jose Maria Guasch, Eduard Borras, Roger Mont, Lluis Porta‐Sanchez, Andreu Roca‐Luque, Ivo affil: Institut Clinic Cardiovascular, Hospital Clínic, Universitat de Barcelona, Barcelona Catalonia,, Spain sug: subj: Ablation Techniques Methods Radiofrequency Ablation Methods Arrhythmia, Ventricular Therapy Patient Safety Evaluation Coronary Vessels Radiation Effects Sinus of Valsalva Radiation Effects Heart Valves Radiation Effects Pulmonary Valve Radiation Effects Treatment Outcomes Evaluation Funding Source Human Male Female Middle Age Hospitals Spain Descriptive Statistics Nonexperimental Studies Retrospective Design Prospective Studies Coronary Angiography Chi Square Test Mann-Whitney U Test Kaplan-Meier Estimator Cox Proportional Hazards Model Univariate Statistics Multivariate Statistics Data Analysis Software Middle Aged: 45-64 years Male Female ab: Background: Radiofrequency (RF) ablation of premature ventricular complexes (PVCs) is a well‐established treatment for patients high PVCs burden, even when arising from epicardial/intramural localization. Consistent data about safety of using high power RF is lacking in the literature in these regions. Aim: The aim of this study is to investigate the safety of different RF power settings, efficacy and outcome of non‐endocardial PVCs ablation. Methods: Consecutive patients who underwent PVC ablation were included (2017–2023). We defined "Non‐Endocardial Radiofrequency Ablation"(NERA) a procedure in which at least one ablation site has been identified into the CVS, aortic cusps, inter‐leaflet region or pulmonary cusps. Results: Total number of NERA sites was 64 in 56 procedures. In 63% of the procedures, high power (≥ 40 W) and in 60% long duration (≥ 60 s) RF was delivered in at least one site (median power: 40 W(30–40), median duration of single RF 54 s(45–91). In 21% of the procedures, a combination of both high power and long duration RF applications was performed. Overall procedural success was achieved in 46 procedures 82%), complete in 39 (70%), partial in 7 (12%). Only one severe complication (pericardial bleeding) was observed. Multisite ablation was associated with procedural failure. During follow‐up, median PVC burden was 0.5%(0.5–9.5), with a median reduction of 97%. Multisite ablation and coronary venous system RF were predictors of recurrence (HR 3.6; p = 0.03) and HR 3.85; p = 0.02). Conclusion: Ablation from non‐endocardial sites is a safe and effective procedure, even using high power and/or long duration RF with clear benefit in terms of PVC burden reduction. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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