Application of cerebrospinal fluid/serum albumin ratio in assessing blood - brain barrier permeability in children with drug-resistant epilepsy.
The cerebrospinal fluid/serum albumin ratio (QAlb) serves as a critical indicator for assessing blood - brain barrier (BBB) permeability. This study aimed to assess BBB permeability in children with drug - resistant epilepsy (DRE) by calculating QAlb and to investigate its correlation with clinical...
| Published in: | Chinese Journal of Contemporary Neurology & Neurosurgery Vol. 25; no. 11; pp. 999 - 1004 |
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| Main Authors: | , , , , , |
| Format: | research tables/charts Journal Article |
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Chinese Journal of Contemporary Neurology & Neurosurgery
Nov2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=190218815&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 190218815 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16726731 FDQ6 jtl: Chinese Journal of Contemporary Neurology & Neurosurgery issn: 16726731 maglogo: N pubinfo: dt: Nov2025 vid: 25 iid: 11 pid: 80951 pub: Chinese Journal of Contemporary Neurology & Neurosurgery artinfo: ui: 190218815 190218815 190218815 10.3969/j.issn.1672-6731.2025.11.004 190218815 ppf: 999 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Application of cerebrospinal fluid/serum albumin ratio in assessing blood - brain barrier permeability in children with drug-resistant epilepsy. aug: au: WANG, Yao MA, Wei CAI, Ao-jie JIN, Pei-na ZHUO, Zhi-hong WANG, Huai-li affil: Department of Pediatrics; He'nan Key Laboratory of Child Epilepsy and Immunological Medicine Research; He'nan Provincial Children's Neurological Disease Clinical Diagnosis and Treatment Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, He'nan, China sug: subj: Cerebrospinal Fluid Serum Albumin Blood-Brain Barrier Permeability Evaluation Drug Resistance Epilepsy Biological Markers Human Headache, Primary Spearman's Rank Correlation Coefficient Correlational Studies Disease Duration Status Epilepticus Seizures Funding Source Child Child: 6-12 years ab: The cerebrospinal fluid/serum albumin ratio (QAlb) serves as a critical indicator for assessing blood - brain barrier (BBB) permeability. This study aimed to assess BBB permeability in children with drug - resistant epilepsy (DRE) by calculating QAlb and to investigate its correlation with clinical characteristics, as well as its potential as a biological marker. Methods A total of 35 children diagnosed with DRE (epilepsy group) and 37 children with primary headache (control group) were admitted to The First Affiliated Hospital of Zhengzhou University between June 2018 and June 2023. QAlb values were derived from laboratory test results. Spearman rank correlation analysis was employed to explore the relationship between QAlb and variables such as disease duration, seizure type, seizure frequency, status epilepticus, and the number of antiepileptic seizure medicine (ASM). Results Compared with control group, the QAlb values were elevated [3.29 (2.39, 4.54) x 10³ vs. 2.15 (1.42, 2.59) x 10³; Z = 4.616, P = 0.000], and the incidence of BBB dysfunction was higher [28.57% (10/35) vs. 2.70% (1/37); χ² = 9.299, P = 0.002] in epilepsy group. Spearman rank correlation analysis indicated a positive correlation between QAlb and both seizure frequency (rs = 0.587, P = 0.000) and the number of ASM (rs = 0.367, P = 0.030) in children with DRE. Conclusions Some children with DRE exhibit BBB dysfunction. QAlb is positively correlated with seizure frequency and the number of ASM, suggesting its potential as a biological marker for identifying BBB dysfunction. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: Chinese refInfo: holdings: @attributes: islocal: N |
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