Ambulatory blood pressure variability in prediction of target organ injury: the SHIP AHOY study.
Background: Ambulatory hypertension is associated with elevated left ventricular mass index (LVMI), cardiac dysfunction, and increased arterial stiffness in adolescents. Whether the addition of measures of BP variability improves the prediction of subclinical cardiovascular target organ damage (TOD)...
| Published in: | Pediatric Nephrology Vol. 41; no. 1; pp. 157 - 166 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Springer Nature
Jan2026
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=190235781&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 190235781 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Jan2026 vid: 41 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 190235781 185254273 190235781 190235781 10.1007/s00467-025-06803-4 190235781 ppf: 157 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Ambulatory blood pressure variability in prediction of target organ injury: the SHIP AHOY study. aug: au: Hanevold, Coral D. Seo, Jang Dong Daniels, Stephen R. Falkner, Bonita E. Ferguson, Michael A. Flynn, Joseph T. Ingelfinger, Julie R. Khoury, Philip R. Lande, Marc B. Meyers, Kevin E. Mitsnefes, Mark Samuels, Joshua Urbina, Elaine M. affil: https://ror.org/00cvxb145 Division of Nephrology, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA sug: subj: Blood Pressure Heart Rate Variability Hypertrophy, Left Ventricular Ventricular Function, Left Blood Pressure Monitoring, Ambulatory Human Anthropometry Heart Rate Multicenter Studies Pulse Wave Velocity Adolescence Descriptive Statistics Male Female Logistic Regression Academic Medical Centers United States United States Sphygmomanometers ROC Curve Funding Source Adolescent: 13-18 years Male Female ab: Background: Ambulatory hypertension is associated with elevated left ventricular mass index (LVMI), cardiac dysfunction, and increased arterial stiffness in adolescents. Whether the addition of measures of BP variability improves the prediction of subclinical cardiovascular target organ damage (TOD) over mean BP measures is not known. Methods: We assessed clinic and ambulatory BP (ABP), anthropometrics, and TOD in 397 adolescents. ABP means standard deviation (SD), BP, and heart rate (HR) dipping were calculated; coefficients of variability (CV) were calculated (SD/mean) to assess ABP variabilities. Measures of TOD included LVMI, left ventricular hypertrophy (LVH), LV systolic shortening, LV diastolic function (e′/a′), and pulse wave velocity. General linear models were used to determine if increased ABP variability measures were significant determinants of TOD in models containing mean ABP percentiles, age, sex, race/ethnicity, BMI z-score, and HR. Results: Mean participant age was 15.6 ± 1.7 years (63% white, 59% male) with mean casual BP 122.6/71.6 mmHg ±12.4/10.5, and mean awake systolic ABP 124.2/72.0 ± 11.3/7.7 mmHg. In linear models, increased awake CV-DBP and HR dipping were significant determinants of LVMI. CV-HR was an independent determinant of diastolic (e′/a′) but not systolic dysfunction. Using logistic regression, the combination of awake and asleep diastolic ABP variability and awake systolic ABP percentile improved the prediction of LVH. Conclusions: Consideration of ABP variability in addition to ABP percentile may aid in identifying adolescents at risk for LVH. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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