Do Patient Preferences and Treatment Beliefs Explain Patterns of Antihypertensive Medication Nonadherence? A Discrete Choice Experiment.
Background: Medication adherence is a critical factor in hypertension management, which remains a challenge for public health systems. Methods: Graded-pair questions were used to quantify the perception of how much nonadherence to antihypertensives increases the risk of serious cardiovascular events...
| Publicado en: | Medical Decision Making Vol. 46; no. 1; pp. 47 - 60 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Jan2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=190255136&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 190255136 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0272989X DKI jtl: Medical Decision Making issn: 0272989X maglogo: Y pubinfo: dt: Jan2026 vid: 46 iid: 1 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 190255136 189223173 190255136 190255136 10.1177/0272989X251388046 190255136 ppf: 47 ppct: 13 formats: tig: atl: Do Patient Preferences and Treatment Beliefs Explain Patterns of Antihypertensive Medication Nonadherence? A Discrete Choice Experiment. aug: au: Tan, Si Ning Germaine Muiruri, Charles Gonzalez Sepulveda, Juan Marcos affil: Duke-NUS Medical School, Singapore sug: subj: Antihypertensive Agents Therapeutic Use Patient Attitudes Medication Compliance Attitude to Medical Treatment Hypertension Drug Therapy Cardiovascular Risk Factors Human Descriptive Statistics Confidence Intervals Convenience Sample Exploratory Research Male Female Interviews Random Assignment Adult Middle Age Aged Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background: Medication adherence is a critical factor in hypertension management, which remains a challenge for public health systems. Methods: Graded-pair questions were used to quantify the perception of how much nonadherence to antihypertensives increases the risk of serious cardiovascular events. A discrete-choice experiment was used to quantify the relative importance of medication outcomes (e.g., reduction in cardiovascular event risk and medication side effects). Rating questions were used to assess perspectives of the effect of treatment nonadherence on treatment side effects. Results were combined to assess how preferences and outcome expectations influence adherence. Results: Patients perceived treatment adherence as the most significant contributor to cardiovascular event risk. A reduction in cardiovascular risk was the most significant consideration when choosing medication. Missing consecutive (v. alternate) doses was associated with greater perceived cardiovascular risk and fewer side effects. The differences between complete adherence and any level of nonadherence were significantly larger for side effects than for changes in the risk of cardiovascular events, suggesting that side effects are perceived to be more sensitive to nonadherence than treatment efficacy. Limitations: Our study relied on hypothetical scenarios, which may not fully capture real-world decision making. While our findings shed light on the relationship between adherence patterns and treatment perceptions, it is essential to recognize the complexity of adherence behavior. Conclusions: Patients believe that they can manage medication side effects by skipping doses without compromising the efficacy to the same degree and that they can offset compromises in efficacy by avoiding missing consecutive doses for prolonged periods. Implications: Health care providers should understand the importance of patient education and counseling to address misconceptions and promote realistic expectations regarding treatment efficacy and the consequences of nonadherence. Highlights: The average patient believes that they can manage medication side effects by skipping doses without compromising the efficacy to the same degree. There is a belief that patients can offset some of the impact of nonadherence on their cardiovascular event risk, particularly if they avoid missing consecutive doses for prolonged periods of time. This highlights the importance of patient education and counseling to address misconceptions and promote realistic expectations regarding treatment efficacy and the consequences of nonadherence. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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