Evaluation of IL-37 and VEGF biomarkers in psoriasis: a comparative study with control subjects.
Introduction: Psoriasis is a persistent, immune-mediated inflammatory skin disease that affects a significant portion of the global population and is often associated with comorbidities, such as cardiovascular diseases and metabolic disorders. The pathogenesis of psoriasis involves complex interacti...
| Publicado en: | Polish Journal of Allergology / Alergologia Polska Vol. 12; no. 4; pp. 265 - 271 |
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| Formato: | research tables/charts Journal Article |
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Termedia Publishing House
Oct-Dec2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=190284323&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 190284323 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23533854 L3AY jtl: Polish Journal of Allergology / Alergologia Polska issn: 23533854 maglogo: N pubinfo: dt: Oct-Dec2025 vid: 12 iid: 4 pid: 24295 pub: Termedia Publishing House place: , <Blank> artinfo: ui: 190284323 190284323 190284323 10.5114/pja.2025.153706 190284323 ppf: 265 ppct: 6 formats: tig: atl: Evaluation of IL-37 and VEGF biomarkers in psoriasis: a comparative study with control subjects. aug: au: Nabat, Zainab Nasser affil: Babylon Technical Institute, Al Furat Al-Awsat Technical University, Babylon, Iraq sug: subj: Psoriasis Physiopathology Psoriasis Therapy Interleukins Blood Vascular Endothelial Growth Factors Blood Biological Markers Blood Disease Duration Severity of Illness Evaluation Treatment Outcomes Human Male Female Child Adolescence Adult Middle Age Severity of Illness Enzyme-Linked Immunosorbent Assay Angiogenesis Inhibitors Drug Effects Cytokines Drug Effects Academic Medical Centers Case Control Studies Volunteer Workers Psychosocial Factors Descriptive Statistics Comparative Studies ROC Curve Questionnaires T-Tests Biopsy Methods Skin Care Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Introduction: Psoriasis is a persistent, immune-mediated inflammatory skin disease that affects a significant portion of the global population and is often associated with comorbidities, such as cardiovascular diseases and metabolic disorders. The pathogenesis of psoriasis involves complex interactions between genetic, immune, and environmental factors, leading to excessive keratinocyte proliferation and inflammation. Aim: This study investigates the role of two critical biomarkers, interleukin-37 (IL-37) and vascular endothelial growth factor (VEGF), in psoriasis; the primary objective was to compare the levels of IL-37 and VEGF in psoriasis patients with varying disease durations and healthy control subjects. Material and methods: The study included 100 participants, with 50 psoriasis patients and 50 healthy controls, with age ranging from 10 to 60 years. Blood samples were collected from each participant and analyzed for IL-37 and VEGF levels using ELISA. Results: The results revealed significantly higher levels of IL-37 and VEGF in psoriasis patients compared to healthy controls (p < 0.001). Moreover, a significant direct correlation was detected between serum IL-37 and VEGF concentrations, on one hand, and both PASI score and disease duration (p < 0.001). Conclusions: These findings support the usefulness of IL-37 and VEGF as biomarkers for assessing disease severity and monitoring treatment efficacy in psoriasis. Moreover, the study opens avenues for exploring IL-37 and VEGF as therapeutic targets to regulate inflammation and angiogenesis in psoriasis patients, potentially improving patient outcomes and informing clinical management strategies. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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