The Effects of Late-Onset Depression on Brain Activity During an Episodic Memory Task.
Introduction: Late-onset depression (LOD) has been implicated in irreversible cognitive decline, potentially mirroring early Alzheimer's Disease (AD) pathology. This study aimed to investigate brain activity differences during an episodic memory (EM) task in LOD patients compared to healthy controls...
| Publicado en: | Archives of Neuropsychiatry / Nöropsikiyatri Arşivi Vol. 62; no. 4; pp. 302 - 310 |
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| Autores principales: | , , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Turkish Association of Neuropsychiatry
Dec2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=190297141&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 190297141 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13000667 84NJ jtl: Archives of Neuropsychiatry / Nöropsikiyatri Arşivi issn: 13000667 maglogo: N pubinfo: dt: Dec2025 vid: 62 iid: 4 pid: 32448 pub: Turkish Association of Neuropsychiatry artinfo: ui: 190297141 190297141 190297141 10.29399/npa.28903 190297141 ppf: 302 ppct: 8 formats: tig: atl: The Effects of Late-Onset Depression on Brain Activity During an Episodic Memory Task. aug: au: GÜLEÇ, Zeynep Naz ERCAN, Melis ERDOĞAN, Yiğit OĞUZ, Kaya UYAR, Aslıhan BURHANOĞLU, Birce Begüm USLU, Özgül ERATA, Mehmet Can EKER, Mehmet Çağdaş GÖNÜL, Ali Saffet affil: SoCAT Lab, Department of Psychiatry, School of Medicine, Ege University, İzmir, Türkiye sug: subj: Depression Delayed Onset Episodic Memory Brain Magnetic Resonance Imaging Human Male Female Middle Age Aged Neuroradiography Alzheimer's Disease Cognition Disorders Psychological Tests Data Analysis Software Mann-Whitney U Test Descriptive Statistics Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Introduction: Late-onset depression (LOD) has been implicated in irreversible cognitive decline, potentially mirroring early Alzheimer's Disease (AD) pathology. This study aimed to investigate brain activity differences during an episodic memory (EM) task in LOD patients compared to healthy controls (HC). Methods: We recruited 15 LOD patients and 13 HC matched for age and gender. Participants completed a face-name association task during functional magnetic resonance imaging (fMRI) focusing on both the encoding and retrieval phases of EM. Results: The statistical contrast between the groups revealed that the HC group showed increased activity in the left visual association cortex (VAC) and left caudate compared to the LOD group during the encoding task. During the face recognition task, the HC group showed increased activity in the right caudate, and during the name recognition task, they showed increased activity in the right frontal eye field (FEF) compared to the LOD group. Conclusion: The differences observed between the HC and LOD groups in the VAC, caudate, and FEF suggest early changes in maintaining attention, goal-directed learning, EM formation, and coordination of information from storage to retrieval before apparent impairment develops in LOD. Although we did not find statistically significant activations in areas linked to increased vulnerability to AD, our findings of hypoactivation in regions responsible for visual processing and attentional orienting in LOD patients are consistent with hypoactivation patterns observed in AD patients in previous research. These results enhance our understanding of the neural mechanisms underlying memory impairments in LOD and their potential overlap with AD pathology. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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