Effects of Paliperidone on Serum D-dimer Levels: Clinical and Experimental Findings.
Background: Dysregulation of coagulation function associated with antipsychotic treatment remains poorly understood. This study investigates the potential impact of paliperidone on serum D-dimer levels during the early stages of treatment. Methods: Nine patients diagnosed with first-episode schizoph...
| Publicado en: | Actas Espanolas de Psiquiatria Vol. 53; no. 5; pp. 959 - 967 |
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| Autores principales: | , , |
| Formato: | Artículo |
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Maria Lopez-Ibor
2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=190365496&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 190365496 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 11399287 IVZ jtl: Actas Espanolas de Psiquiatria issn: 11399287 maglogo: N pubinfo: dt: 2025 vid: 53 iid: 5 pid: 80014 pub: Maria Lopez-Ibor artinfo: ui: 190365496 10.62641/aep.v53i5.1958 ppf: 959 ppct: 8 formats: fmt: @attributes: type: P size: 1.6MB tig: atl: Effects of Paliperidone on Serum D-dimer Levels: Clinical and Experimental Findings. aug: au: Mou, Tingting Lai, Jianbo Kong, Lingzhuo affil: Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, 310003 Hangzhou, Zhejiang, China. Zhejiang Key Laboratory of Precision Psychiatry, 310003 Hangzhou, Zhejiang, China. Brain Research Institute of Zhejiang University, 310012 Hangzhou, Zhejiang, China. Zhejiang Engineering Center for Mathematical Mental Health, 310003 Hangzhou, Zhejiang, China. MOE Frontier Science Center for Brain Science and Brain-machine Integration, Zhejiang University School of Medicine, 310058 Hangzhou, Zhejiang, China. su: Blood coagulation Antipsychotic agents Schizophrenia Treatment effectiveness Blood coagulation factors Medical research Animal experimentation sug: subj: Blood coagulation Antipsychotic agents Schizophrenia Treatment effectiveness Blood coagulation factors Medical research Animal experimentation keyword: blood coagulation paliperidone schizophrenia ab: Background: Dysregulation of coagulation function associated with antipsychotic treatment remains poorly understood. This study investigates the potential impact of paliperidone on serum D-dimer levels during the early stages of treatment. Methods: Nine patients diagnosed with first-episode schizophrenic spectrum disorder were assessed for serum D-dimer levels before and after a 2-week paliperidone regimen. Additionally, eight adult C57 mice in the experimental group (EG) received 3 mg/kg of paliperidone daily for 10 consecutive days, while eight mice in the control group (CG) were untreated. Venous blood was collected and analyzed for D-dimer at baseline, and on the 5th and 10th days in the EG, as well as on the 10th day for the CG. Results: No significant differences were observed in serum D-dimer levels before and after paliperidone treatment in the patient cohort. In animal experiments, compared to the CG on the 10th day, serum D-dimer levels in the EG on the 10th day showed no significant difference (p > 0.05), while the level in the EG on the 5th day was significantly lower (p < 0.05). Compared to its baseline, serum D-dimer levels within the EG on the 5th day was significantly decreased (p < 0.05). Conclusion: Short-term paliperidone treatment had minimal effects on serum D-dimer levels in both human participants and mice, though transient changes were noted early in treatment. Nonetheless, the potential for druginduced coagulation disruption should be considered in clinical practice. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Actas Espanolas de Psiquiatria holder: Maria Lopez-Ibor dt: @attributes: year: 2025 holdings: @attributes: islocal: N |
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