Renal and cardiovascular function in children with FASD: Potential links to food approach and avoidance behaviors.
Background: Fetal alcohol spectrum disorder (FASD) is associated with a range of developmental, behavioral, and physical impairments. While much research to date has focused on developmental and behavioral aspects of FASD, there is growing evidence that children with FASD may experience alterations...
| Publicado en: | Alcohol, Clinical & Experimental Research Vol. 49; no. 12; pp. 2695 - 2707 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Dec2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=190433692&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 190433692 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 29937175 NACB jtl: Alcohol, Clinical & Experimental Research issn: 29937175 maglogo: N pubinfo: dt: Dec2025 vid: 49 iid: 12 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 190433692 189324446 190433692 190433692 10.1111/acer.70200 190433692 ppf: 2695 ppct: 12 formats: tig: atl: Renal and cardiovascular function in children with FASD: Potential links to food approach and avoidance behaviors. aug: au: Reid, Natasha Logan, Jayden Garavelis, Khari Yang, Jinyang Hayes, Nicole Vanderpeet, Chelsea Liddle, Karen Young, Sophia Maloney, Maree Sullivan, Emily Moritz, Karen Akison, Lisa affil: Child Health Research Centre, The University of Queensland, Brisbane Queensland,, Australia sug: subj: Fetal Alcohol Syndrome Physiopathology Cardiovascular System Physiopathology Kidney Physiopathology Eating Behavior Evaluation Eating Behavior Evaluation Avoidance (Psychology) Evaluation Human Male Female Child, Preschool Child Adolescence Australia Academic Medical Centers Australia Exploratory Research Comparative Studies Descriptive Statistics Data Analysis Software Questionnaires Caregivers Self Report Pearson's Correlation Coefficient Chi Square Test Fisher's Exact Test Unpaired T-Tests Mann-Whitney U Test Spearman's Rank Correlation Coefficient Body Weight Body Height Anthropometry Age Factors Sex Factors Urinalysis Electrolytes Urine Potassium Urine Chlorides Urine Creatinine Urine Osmolar Concentration Heart Rate Evaluation Blood Pressure Evaluation Blood Pressure Determination Blood Pressure Devices Child Behavior Adolescent Behavior Biological Markers Urine Eating Disorders Risk Factors Risk Assessment Avoidance Learning Evaluation Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years Male Female ab: Background: Fetal alcohol spectrum disorder (FASD) is associated with a range of developmental, behavioral, and physical impairments. While much research to date has focused on developmental and behavioral aspects of FASD, there is growing evidence that children with FASD may experience alterations in renal and cardiovascular function. By also comparing eating behaviors between children with FASD and typically developing children, this may provide some clues to the underlying causes of these physiological changes. Methods: In this study, we recruited children and adolescents with (n = 34) and without (n = 22) a diagnosis of FASD. We measured several cardiovascular and renal outcomes and analyzed potential associations with eating behaviors related to food approach and avoidance, assessed from caregiver report using the Children's Eating Behavior Questionnaire (CEBQ). Results: Children with FASD had significantly elevated urinary sodium‐to‐potassium (Na+/K+) ratio, a trend for increasing urine sodium (Na+), and a reduction in the normal age‐associated rise in urine creatinine compared to typically developing controls. The FASD group also exhibited significantly elevated resting heart rate. Additionally, those with a diagnosis of FASD had higher scores for subscales of food approach (food responsiveness, emotional overeating, desire to drink) and a trend toward a higher food avoidance score on the CEBQ. A subset of these behavioral scores was associated with cardiovascular but not renal outcomes. Conclusions: Together, these findings suggest that renal and cardiovascular function may be altered in children and adolescents with FASD, which may be linked to abnormal food‐related behaviors and/or other clinical or demographic factors. While the mechanisms underlying these early‐life physiological changes are not fully understood, it is likely they contribute to poorer long‐term health outcomes. Further research is needed to validate these preliminary findings in larger cohorts, explore the underlying mechanisms and investigate potential long‐term implications of these findings. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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