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Cutaneous and Genitalia Inflammation Treated With Guselkumab and Antimicrobial Therapy in a Patient with a History of Crohn's Disease.

Cutaneous Crohn's disease (CD) is a rare manifestation of inflammatory bowel disease characterized by cutaneous lesions that are noncontiguous with gastrointestinal tissue yet share similar histopathologic features with gastrointestinal CD. To our knowledge, there are no published data on the use of...

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Published in:ACG Case Reports Journal Vol. 12; no. 12; pp. 1 - 5
Main Authors: Nikzad, Newsha, Khadilkar, Surya, Darkwa, Oluwakemi Onajin, Gradwohl, Kelsey Mann, Chadha, Angad A., Pekow, Joel, Rubin, David T.
Format: case study pictorial tables/charts Journal Article
Published: American College of Gastroenterology Dec2025
Online Access:View this record in EBSCOhost
Summary:Cutaneous Crohn's disease (CD) is a rare manifestation of inflammatory bowel disease characterized by cutaneous lesions that are noncontiguous with gastrointestinal tissue yet share similar histopathologic features with gastrointestinal CD. To our knowledge, there are no published data on the use of guselkumab for cutaneous CD. We discuss a case of concomitant pyoderma gangrenosum and cutaneous CD treated with a novel combination of guselkumab, antimicrobial agents, and corticosteroids.