Ketamine Infusion as a Single Sedative Agent for Post-Intubation Management of Critically Ill Patients: A Systematic Review and Meta-Analysis.
Introduction: Combining multiple drugs for intubation raises concerns such as increased side effects, medication errors, nursing workload, and costs. Ketamine, with its anesthetic and analgesic properties, shows promise as a sedative agent for post-intubation care. This study aimed to evaluate the e...
| Publicado en: | Archives of Academic Emergency Medicine Vol. 13; no. 1; pp. 1 - 11 |
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| Autores principales: | , , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Shahid Beheshti University of Medical Sciences
2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=190500690&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 190500690 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 26454904 MFMK jtl: Archives of Academic Emergency Medicine issn: 26454904 maglogo: N pubinfo: dt: 2025 vid: 13 iid: 1 pid: 87963 pub: Shahid Beheshti University of Medical Sciences artinfo: ui: 190500690 190500690 190500690 10.22037/aaemj.v13i1.2598 190500690 ppf: 1 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Ketamine Infusion as a Single Sedative Agent for Post-Intubation Management of Critically Ill Patients: A Systematic Review and Meta-Analysis. aug: au: Maghraby, Nisreen Ahmed Almulihi, Qasem Nemeth, Joe Alghanim, Mohammed Hajay Barbic, David Al Rajeh, Ibrahim Khalil Haji, Arwaa Khalid M. affil: KFHU Emergency Medicine Department, College of Medicine, Imam Abdulrahman bin Faisal University, Kingdom of Saudi Arabia. sug: subj: Critical Illness Drug Therapy Critically Ill Patients Psychosocial Factors Ketamine Therapeutic Use Hypnotics and Sedatives Therapeutic Use Intubation, Intratracheal Infusions, Intravenous Critical Care Drug Efficacy Patient Safety Human Female Male Systematic Review Meta Analysis Medline Cochrane Library Descriptive Statistics Checklists Odds Ratio Conscious Sedation Methods Confidence Intervals Atrial Fibrillation Agitation Ketamine Adverse Effects Data Analysis Software Female Male ab: Introduction: Combining multiple drugs for intubation raises concerns such as increased side effects, medication errors, nursing workload, and costs. Ketamine, with its anesthetic and analgesic properties, shows promise as a sedative agent for post-intubation care. This study aimed to evaluate the efficacy and safety of ketamine infusion as the sole sedative for critically ill intubated patients. Methods: Following PRISMA 2020 guidelines, we conducted a systematic review by searching Ovid MEDLINE, Cochrane Central Register of Controlled Trials, and Google Scholar up to May 10, 2024. We included studies assessing ketamine use for post-intubation sedation in critically ill adults or children. Study quality was assessed using the Newcastle–Ottawa scale, and meta-analysis was performed using a random-effects model. Results: The systematic review included 7 studies, with 4 studies included in the meta-analysis. There was no significant difference in mortality (OR = 1.52; 95% CI: 0.49–4.70, p = 0.46; I2 = 83%) or length of hospital stay (MD = 6.42; 95% CI: -1.42-14.26, p = 0.11; I2 = 84%) between the ketamine only and other groups. The most common adverse events in the ketamine infusion group were atrial fibrillation and agitation. Conclusion: Single-agent ketamine infusion is effective and safe for critically ill intubated patients. No significant differences were found in mortality or hospital stay between ketamine only and other groups. Atrial fibrillation and agitation were the most common adverse effects. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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