Dual- energy CT versus single-energy CT for estimation of hematocrit and hemoglobin in the brain: an in vivo analysis.
Purpose: Hematocrit (Hct) and hemoglobin (HB) levels in blood are known to be correlated with vascular attenuation values on single-energy computed tomography (SECT). Dual-energy computed tomography (DECT) is likely to have even better correlations than SECT, given its richer information content, bu...
| Published in: | Neuroradiology Vol. 67; no. 11; pp. 3147 - 3156 |
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| Main Authors: | , , , , , , |
| Format: | diagnostic images equations & formulas research tables/charts Journal Article |
| Published: |
Springer Nature
Nov2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=190505800&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 190505800 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Nov2025 vid: 67 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 190505800 186619300 190505800 190505800 10.1007/s00234-025-03700-3 190505800 ppf: 3147 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Dual- energy CT versus single-energy CT for estimation of hematocrit and hemoglobin in the brain: an in vivo analysis. aug: au: Dagher, Richard Jacobsen, Megan C Vasireddy, Satvik Layman, Rick R Kim, Dong-Eog Wintermark, Max Schellingerhout, Dawid affil: https://ror.org/04twxam07 The University of Texas MD Anderson Cancer Center, Houston, TX, United States sug: subj: Tomography, X-Ray Computed Methods Radiographic Image Enhancement Hematocrit Evaluation Hemoglobins Analysis Brain Radiography Human Male Female Adult Middle Age Aged Aged, 80 and Over In Vivo Studies Funding Source Contrast Media Diagnostic Use Iodine Pharmacodynamics Water Metabolism Brain Blood Supply Nervous System Diseases Complications Nervous System Diseases Radiography Pearson's Correlation Coefficient Linear Regression Artifacts Cranial Sinuses Radiography Contrast Media Administration and Dosage Multiple Regression Descriptive Statistics Data Analysis Software Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Purpose: Hematocrit (Hct) and hemoglobin (HB) levels in blood are known to be correlated with vascular attenuation values on single-energy computed tomography (SECT). Dual-energy computed tomography (DECT) is likely to have even better correlations than SECT, given its richer information content, but this remains unproven clinically. We compare and contrast DECT and SECT correlations between attenuation in the superior sagittal sinus (SSS) to patient Hct/HB levels, and explore the use of iodine/water decomposition maps for the same purpose. Methods: Brain SECT and DECT were acquired contemporaneously in 83 patients and attenuation was measured in the SSS on SECT, monoenergetic DECT images (40 to 140 keV in 5 keV increments) and DECT material decomposition images (water and iodine). Hct/HB values were from complete blood counts (CBC) within 30 days of imaging. Linear regressions were performed to Hct/HB using the measured attenuations as explanatory variables. Results: Hct and HB were strongly mutually correlated (r = 0.964). Hct/HB were moderately correlated (r = 0.493/0.458) with SSS attenuation on SECT, and moderately to strongly correlated for DECT (Pearson's r ranging 0.331–0.656) over a range of monoenergetic levels (40 to 140 keV). Above 60 keV, DECT monoenergetic images were better correlated to Hct/HB than SECT, with correlation maximized at 95 keV (r = 0.656, p < 0.001). Material decomposition water images had moderate correlation (r = 0.51), improving to strong correlation (r = 0.659) for a two-variable water and iodine regression, similar to the monoenergetic results. Conclusion: DECT has better correlations to Hct/HB than SECT for all monoenergetic energies above 60 keV, with best correlations at 95 keV. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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