Predicting pragmatic language abilities from brain structural MRI in preschool children with ASD by NBS-Predict.
Pragmatics plays a crucial role in effectively conveying messages across various social communication contexts. This aspect is frequently highlighted in the challenges experienced by children diagnosed with autism spectrum disorder (ASD). Notably, there remains a paucity of research investigating ho...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 34; no. 12; pp. 3779 - 3791 |
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| Autores principales: | , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=190506454&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 190506454 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Dec2025 vid: 34 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 190506454 185830861 190506454 190506454 10.1007/s00787-025-02775-w 190506454 ppf: 3779 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Predicting pragmatic language abilities from brain structural MRI in preschool children with ASD by NBS-Predict. aug: au: Qian, Lu Ding, Ning Fang, Hui Xiao, Ting Sun, Bei Gao, HuiYun Ke, XiaoYan affil: https://ror.org/01wcx2305 Child Mental Health Research Center, Nanjing Brain Hospital Affiliated of Nanjing Medical University, Nanjing Guangzhou Road 264#, 210029, Nanjing, China sug: subj: Brain Anatomy and Histology Magnetic Resonance Imaging Autism Spectrum Disorder Diagnosis Diagnosis, Neurologic White Matter Pathology Machine Learning Prediction Models Human Male Female Child, Preschool Child China Case Control Studies Discriminant Analysis Sensitivity and Specificity Linear Regression Pearson's Correlation Coefficient Funding Source Scales Child, Preschool: 2-5 years Child: 6-12 years Male Female ab: Pragmatics plays a crucial role in effectively conveying messages across various social communication contexts. This aspect is frequently highlighted in the challenges experienced by children diagnosed with autism spectrum disorder (ASD). Notably, there remains a paucity of research investigating how the structural connectome (SC) predicts pragmatic language abilities within this population. Using diffusion tensor imaging (DTI) and deterministic tractography, we constructed the whole-brain white matter structural network (WMSN) in a cohort comprising 92 children with ASD and 52 typically developing (TD) preschoolers, matched for age and gender. We employed network-based statistic (NBS)-Predict, a novel methodology that integrates machine learning (ML) with NBS, to identify dysconnected subnetworks associated with ASD, and then to predict pragmatic language abilities based on the SC derived from the whole-brain WMSN in the ASD group. Initially, NBS-Predict identified a subnetwork characterized by 42 reduced connections across 37 brain regions (p = 0.01), achieving a highest classification accuracy of 79.4% (95% CI: 0.791 ~ 0.796). The dysconnected regions were predominantly localized within the brain's frontotemporal and subcortical areas, with the right superior medial frontal gyrus (SFGmed.R) emerging as the region exhibiting the most extensive disconnection. Moreover, NBS-Predict demonstrated that the optimal correlation coefficient between the predicted pragmatic language scores and the actual measured scores was 0.220 (95% CI: 0.174 ~ 0.265). This analysis revealed a significant association between the pragmatic language abilities of the ASD cohort and the white matter connections linking the SFGmed.R with the bilateral anterior cingulate gyrus (ACG). In summary, our findings suggest that the subnetworks displaying the most significant abnormal connections were concentrated in the frontotemporal and subcortical regions among the ASD group. Furthermore, the observed abnormalities in the white matter connection pathways between the SFGmed.R and ACG may underlie the neurobiological basis for pragmatic language deficits in preschool children with ASD. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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