Association Between Fat Mass Index, Fat Free Mass Index and Metabolic Syndrome, Cachexia, and All-Cause Mortality Among Patients with Cancer.
Background and Objective: This study examined the associations of fat mass index (FMI) and fat free mass index (FFMI) with metabolic syndrome (MetS), cachexia, and all-cause mortality in cancer patients, given the limited existing evidence on these relationships. Materials and Methods: This analysis...
| Publicado en: | Nutrition & Cancer Vol. 78; no. 2; pp. 123 - 134 |
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| Autores principales: | , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=190553129&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 190553129 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2026 vid: 78 iid: 2 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 190553129 189120863 190553129 190553129 10.1080/01635581.2025.2581336 190553129 ppf: 123 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Association Between Fat Mass Index, Fat Free Mass Index and Metabolic Syndrome, Cachexia, and All-Cause Mortality Among Patients with Cancer. aug: au: Tian, Hai-Ying Liu, Chen-An Shi, Han-Ping affil: Department of oncology, Daxing Teaching Hospital, Capital Medical University, Beijing, China sug: subj: Body Mass Index Fat Free Mass Metabolic Syndrome X Cachexia Cause of Death Cancer Patients Psychosocial Factors Body Composition Human Male Female Middle Age Aged Logistic Regression Cox Proportional Hazards Model Confidence Intervals Odds Ratio Multicenter Studies China Wilcoxon Rank Sum Test Chi Square Test Spearman's Rank Correlation Coefficient Prospective Studies Mediation Analysis Funding Source Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background and Objective: This study examined the associations of fat mass index (FMI) and fat free mass index (FFMI) with metabolic syndrome (MetS), cachexia, and all-cause mortality in cancer patients, given the limited existing evidence on these relationships. Materials and Methods: This analysis included 3,247 subjects enrolled in a cohort study. Cox regression analyses calculated hazard ratios (HRs) with corresponding 95% confidence intervals (95% CIs). Logistic models generated odds ratios (ORs) and 95% CIs. Mediation effects of FMI and FFMI on the cachexia-mortality association were evaluated. Results: FMI and FFMI were significantly associated with MetS and cachexia, respectively. FMI (HR [95% CI] = 0.96 (0.94, 0.99), p = 0.003), FFMI (HR [95% CI] = 0.94 (0.91, 0.97), p < 0.001) were significantly associated with mortality. FMI (proportion mediated%=10.21, p = 0.03) and FFMI (proportion mediated%=13.16, p = 0.016) mediate the correlation between cachexia and mortality. Subgroup analysis showed that FMI had a significant mediating effect in gastrointestinal cancer, while FFMI had a significant mediating effect in lung cancer. Conclusion: FMI and FFMI were positively correlated with MetS, negatively correlated with cachexia and mortality. FMI and FFMI mediate the association between cachexia and mortality, with FFMI having a higher mediating effect than FMI, however, the mediating effect was differentiated by tumor types. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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