A scoping review of randomised controlled trials of vaccines that recruited care home residents: lessons for future trials.
Introduction Older care home (CH) residents are particularly vulnerable to infections and often experience adverse outcomes. Despite this group being frequently prioritised for vaccinations, trials of vaccines rarely recruit CH residents. Given that the social and biological characteristics of CH re...
| Publicado en: | Age & Ageing Vol. 54; no. 12; pp. 1 - 13 |
|---|---|
| Autores principales: | , , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Oxford University Press / USA
Dec2025
|
| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=190592519&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 190592519 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Dec2025 vid: 54 iid: 12 pid: 622 pub: Oxford University Press / USA artinfo: ui: 190592519 10.1093/ageing/afaf355 ppf: 1 ppct: 12 formats: tig: atl: A scoping review of randomised controlled trials of vaccines that recruited care home residents: lessons for future trials. aug: au: Subbarayan, Selvarani Smith-Dodd, Imogen Nicolson, Gabriel Burton, Jennifer Kirsty Scott, Janet T Vasan, Seshadri S Shenkin, Susan D Soiza, Roy L Consortium, The WATCH affil: Ageing Clinical and Experimental Research Group, The Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UKAberdeen Royal Infirmary, NHS Grampian, Aberdeen, UK Ageing Clinical and Experimental Research Group, The Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK Academic Geriatric Medicine, School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK Research, Development and Innovation, NHS Highland, Inverness, UKSchool of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UKCentre for Virus Research, University of Glasgow, Glasgow, UK Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, UKSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Australia Ageing and Health, and Advanced Care Research Centre, Usher Institute, The University of Edinburgh, Edinburgh, UK su: Human research subjects Influenza vaccines Randomized controlled trials Nursing care facilities Patient participation Old age Patient selection Medical information storage & retrieval systems CINAHL database Descriptive statistics Systematic reviews MEDLINE Pneumococcal vaccines Medical databases Data analysis software Psychology information storage & retrieval systems sug: subj: Human research subjects Influenza vaccines Randomized controlled trials Nursing care facilities Patient participation Old age Nursing Care Facilities (Skilled Nursing Facilities) Community care facilities for the elderly Patient selection Medical information storage & retrieval systems CINAHL database Descriptive statistics Systematic reviews MEDLINE Pneumococcal vaccines Medical databases Data analysis software Psychology information storage & retrieval systems keyword: barriers and facilitators care home residents internship and residency medical residencies nursing home residents older people randomised controlled vaccine trials randomization recruitment and retention vaccine clinical trial vaccines barriers and facilitators care home residents internship and residency medical residencies nursing home residents older people randomised controlled vaccine trials randomization recruitment and retention vaccine clinical trial vaccines ab: Introduction Older care home (CH) residents are particularly vulnerable to infections and often experience adverse outcomes. Despite this group being frequently prioritised for vaccinations, trials of vaccines rarely recruit CH residents. Given that the social and biological characteristics of CH residents may influence vaccine effectiveness, it is crucial to test vaccines in this population. Methods The Widening Access to Trials in Care Homes project was established to develop best practice guidance on designing and conducting vaccine trials in the CH population. As part of this project, a scoping review following Joanna Briggs Institute methodology was conducted to identify vaccine trials involving CH residents. Search conducted in EMBASE, MEDLINE, PsycINFO, CINAHL and Cochrane Library, from 1990 to 2025. Results presented as descriptive summaries. Results We retrieved 701 articles and included 20 studies. A total of 7479 participants from 238 CHs were recruited to influenza or pneumococcal vaccine trials. The weighted mean age was 82.3 years. Screen failure averaged 70% (eight studies), primarily due to declining participation (46%) and not meeting eligibility criteria (27%). Dropout averaged 8% (11 studies), with death (21%) being the most common reason. Identified barriers include eligibility criteria and recruitment, consent and assent issues, ethical and regulatory, CH-related factors and study time frame and logistical factors. Facilitators include recruitment and data collection methods, consent and assent factors and collaboration with CHs. Conclusion Our review is the first to synthesise both quantitative and qualitative evidence on recruiting CH residents into vaccine trials and to provide suggestions for future trial design in this population. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
|---|