The association between gut microbiota-derived metabolites and arterial stiffness in hypertensive patients.
The present study aimed at investigating the association of gut microbial metabolites with arterial stiffness in patients with hypertension. This cross-sectional study was conducted on 120 hypertensive patients attending Tashkent clinics. Assessments included measurement of plasma levels of TMAO met...
| Publicado en: | Revista Latinoamericana de Hipertensión Vol. 20; no. 11; pp. 818 - 825 |
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| Autores principales: | , , , , , , |
| Formato: | Artículo |
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Revista Latinoamericana de Hipertension
2025
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=190639123&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 190639123 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 18564550 FICN jtl: Revista Latinoamericana de Hipertensión issn: 18564550 maglogo: N pubinfo: dt: 2025 vid: 20 iid: 11 pid: 81901 pub: Revista Latinoamericana de Hipertension artinfo: ui: 190639123 10.5281/zenodo.17925018 ppf: 818 ppct: 7 formats: fmt: @attributes: type: P size: 918KB tig: atl: The association between gut microbiota-derived metabolites and arterial stiffness in hypertensive patients. aug: au: Ibragimova, Feruza Kalenderova, Guljakhan Kalmuratova, Bibigul Okhunova, Munojoat Kholmuradova, Zilola Ikramova, Feruza Axmedov, Nodir affil: Associate Professor of the department of orthopedic dentistry and orthodontics, Bukhara State Medical Institute, Bukhara, Uzbekistan Assistant teacher, Department of Preventive Medicine, Folk Medicine and Neurology, Karakalpakstan Medical Institute, Nukus, Republic of Uzbekistan Kokand State University, Kokand, Republic of Uzbekistan Assistant of the Department of Pediatrics, Faculty of Medicine, Samarkand State Medical University, Samarkand, Republic of Uzbekistan Endocrinologist at the Bukhara Regional Endocrinology Dispensary", Republic of Uzbekistan su: Gut microbiota Microbial metabolites Hypertension Pulse wave analysis Microbiota Metabolites Butyrates Arterial diseases sug: subj: Gut microbiota Microbial metabolites Hypertension Pulse wave analysis Microbiota Metabolites Butyrates Arterial diseases keyword: Arterial Stiffness Gut Microbiota Microbial Metabolites Hipertensión Metabolitos microbianos Microbiota intestinal Rigidez arterial ab: The present study aimed at investigating the association of gut microbial metabolites with arterial stiffness in patients with hypertension. This cross-sectional study was conducted on 120 hypertensive patients attending Tashkent clinics. Assessments included measurement of plasma levels of TMAO metabolites and SCFAs, arterial stiffness measured by the carotid-femoral pulse wave velocity method, and analysis of the microbiota composition. The study results indicated that TMAO levels were positively and significantly associated with the cf-PWV index, with a correlation coefficient of 0.48 (p < 0.001). On the other hand, butyrate was negatively associated with cf-PWV, with a correlation coefficient of -0.42 (p < 0.001). Multiple regression analysis presented both metabolites to be independently associated with arterial stiffness: the beta coefficient for TMAO was 0.35 and for butyrate was -0.28. When comparing different metabolic quartiles, the levels of cf-PWV were significantly higher for those patients with high TMAO levels: 11.2 vs. 8.5 m/s (p < 0.001). Moreover, microbiological analyses showed that richness in particular bacterial genera was significantly associated with metabolite levels. The results from this study confirm that gut microbial metabolites play an independent role in the pathophysiology of arterial stiffness and may provide novel strategies for risk assessment and therapeutic interventions in patients with hypertension. El presente estudio tuvo como objetivo investigar la asociación de los metabolitos microbianos intestinales con la rigidez arterial en pacientes hipertensos. Este estudio transversal se realizó en 120 pacientes hipertensos que acudían a clínicas de Tashkent. Las evaluaciones incluyeron la medición de los niveles plasmáticos de metabolitos de TMAO y AGCC, la rigidez arterial medida mediante el método de velocidad de la onda de pulso carótido-femoral y el análisis de la composición de la microbiota. Los resultados del estudio indicaron que los niveles de TMAO se asociaron de forma positiva y significativa con el índice cf-PWV, con un coeficiente de correlación de 0,48 (p < 0,001). Por otro lado, el butirato se asoció negativamente con el cf-PWV, con un coeficiente de correlación de -0,42 (p < 0,001). El análisis de regresión múltiple mostró que ambos metabolitos se asociaban de forma independiente con la rigidez arterial: el coeficiente beta para TMAO fue de 0,35 y para butirato, de -0,28. Al comparar diferentes cuartiles metabólicos, los niveles de cf-PWV fueron significativamente mayores en los pacientes con niveles elevados de TMAO: 11,2 frente a 8,5 m/s (p < 0,001). Además, los análisis microbiológicos mostraron que la riqueza de géneros bacterianos específicos se asociaba significativamente con los niveles de metabolitos. Los resultados de este estudio confirman que los metabolitos microbianos intestinales desempeñan un papel independiente en la fisiopatología de la rigidez arterial y podrían proporcionar nuevas estrategias para la evaluación del riesgo y las intervenciones terapéuticas en pacientes con hipertensión. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Revista Latinoamericana de Hipertensión is the property of Revista Latinoamericana de Hipertension and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Revista Latinoamericana de Hipertensión holder: Revista Latinoamericana de Hipertension dt: @attributes: year: 2025 holdings: @attributes: islocal: N |
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