Air pollution and breast cancer risk: a Mendelian randomization study.
Previous research yields inconsistent findings on the association between air pollution and breast cancer risk, with no definitive causal relationship established. To address this, we conducted a two-sample Mendelian randomization study on data from the IEU open GWAS databases and the Breast Cancer...
| Publicado en: | International Journal of Environmental Health Research Vol. 36; no. 1; pp. 30 - 41 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Jan2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=190647843&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 190647843 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09603123 57L jtl: International Journal of Environmental Health Research issn: 09603123 maglogo: Y pubinfo: dt: Jan2026 vid: 36 iid: 1 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 190647843 182140448 190647843 190647843 10.1080/09603123.2025.2451622 190647843 ppf: 30 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Air pollution and breast cancer risk: a Mendelian randomization study. aug: au: Cao, Kangdi Wang, Jinkun Hou, Wei affil: Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China sug: subj: Breast Neoplasms Air Pollution Risk Factors Environmental Exposure Adverse Effects Risk Assessment Environmental Health Human Funding Source Mendelian Randomization Descriptive Statistics Data Analysis Software Odds Ratio Confidence Intervals HER-2-neu Oncogene ab: Previous research yields inconsistent findings on the association between air pollution and breast cancer risk, with no definitive causal relationship established. To address this, we conducted a two-sample Mendelian randomization study on data from the IEU open GWAS databases and the Breast Cancer Association Consortium to explore the potential link between air pollution (including PM2.5, PM2.5 absorbance, PM2.5–10, PM10, NO2, and NOx) and breast cancer risk. We found that PM10 (odds ratio (OR) = 1.39, 95% CI: 1.07–1.80, p = 0.013) and NOx (OR = 1.67, 95% CI: 1.16–2.41, p = 0.006) were significantly associated with elevated breast cancer risk. Furthermore, PM2.5 (OR = 2.10, 95% CI: 1.09–4.03, p = 0.027) and NOx (OR = 3.08, 95% CI: 1.24–7.64, p = 0.015) were significantly associated with an elevated risk of luminal B/HER2-negative-like cancer. Results were stable in sensitivity analyses. This suggested that controlling air pollution could potentially reduce breast cancer risk. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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