Comparison of bone age assessment using manual Greulich and Pyle method versus automated BoneXpert method in South African children.

Background: The Greulich and Pyle (GP) method is the most commonly used manual bone age assessment method but it is associated with interrater variability. The BoneXpert method is fully automated, eliminates interrater variability and has been validated for use in various populations. Objectives: To...

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Publicado en:South African Journal of Radiology Vol. 29; no. 1; pp. 1 - 11
Autores principales: Minty, Radhiya, Mahomed, Nasreen, van Wyk, Nicole, Mndebele, Gopolang, Lockhat, Zarina, Ranchod, Ashesh
Formato: diagnostic images research tables/charts Journal Article
Publicado: African Online Scientific Information System PTY LTD 2025
Acceso en línea:Ver este registro en EBSCOhost
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        atl: Comparison of bone age assessment using manual Greulich and Pyle method versus automated BoneXpert method in South African children.
      aug:
        au:
          Minty, Radhiya
          Mahomed, Nasreen
          van Wyk, Nicole
          Mndebele, Gopolang
          Lockhat, Zarina
          Ranchod, Ashesh
        affil: Department of Radiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
      sug:
        subj:
          Endocrine Diseases In Infancy and Childhood
          Age Determination by Skeleton In Infancy and Childhood
          Age Determination by Skeleton Methods
          Automation
          Artificial Intelligence
          South Africa
          Human
          Male
          Female
          Multicenter Studies
          Comparative Studies
          Descriptive Statistics
          Technology
          Bone and Bones Anatomy and Histology
          Hand Radiography
          Wrist Radiography
          Data Analysis Software
          Infant
          Child, Preschool
          Child
          Adolescence
          Algorithms
          Growth Disorders
          Infant: 1-23 months
          Child, Preschool: 2-5 years
          Child: 6-12 years
          Adolescent: 13-18 years
          Male
          Female
      ab: Background: The Greulich and Pyle (GP) method is the most commonly used manual bone age assessment method but it is associated with interrater variability. The BoneXpert method is fully automated, eliminates interrater variability and has been validated for use in various populations. Objectives: To compare the manual GP method with the automated BoneXpert method in performing bone age assessment of children with various paediatric endocrinology diagnoses. Method: Three manual readers performed manual bone age assessment, and BoneXpert software performed automated bone age assessment on 260 left hand-wrist radiographs. Images where the average of three manual readers (Manual BA) deviated from BoneXpert BA by > 1.5 years, were re-read by an external reader, producing a Reference BA. Manual BA was compared to Carpal BA that was produced by the software. A composite bone age (Comp BA) for the software was defined to estimate the weighting on carpal and tubular bones to achieve the best agreement with Manual BA. Results: The interclass correlation (ICC) between each manual reader was > 0.9, indicating a high positive correlation. The ICC between Manual BA and BoneXpert BA was 0.982. The Comp BA for BoneXpert that would achieve the best fit with Manual BA, places a 50% weighting on Carpal BA and 50% weighting on Tubular BA. Conclusion: The BoneXpert method is efficient, well-validated and shows a positive correlation with the manual GP method. An estimated weightage of 50% to carpal bones and 50% to tubular bones resulted in an automated Comp BA with the best agreement with Manual BA. Contribution: This original research article compares manual and automated bone age assessment methods to evaluate the use of artificial intelligence tools in the South African context.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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