Colchicine for the Secondary Prevention of Cardiovascular Diseases: A Cumulative-Dose Meta-analysis of Randomized Controlled Trials including 31,397 Subjects Worldwide.
Background: Colchicine has been incorporated into major clinical guidelines for the secondary prevention of cardiovascular disease (CVD). However, recent randomized trials have presented contradictory results. Objective: We aimed to synthesize the current evidence on colchicine in secondary CVD prot...
| Publicado en: | American Journal of Cardiovascular Drugs Vol. 26; no. 1; pp. 107 - 121 |
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| Autores principales: | , , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=190750840&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 190750840 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11753277 G7S jtl: American Journal of Cardiovascular Drugs issn: 11753277 maglogo: N pubinfo: dt: Jan2026 vid: 26 iid: 1 pid: 87227 pub: Springer Nature artinfo: ui: 190750840 187660695 190750840 190750840 10.1007/s40256-025-00743-y 190750840 ppf: 107 ppct: 14 formats: tig: atl: Colchicine for the Secondary Prevention of Cardiovascular Diseases: A Cumulative-Dose Meta-analysis of Randomized Controlled Trials including 31,397 Subjects Worldwide. aug: au: Li, Hoi-Ying Cheriyan, Joseph Chan, Tsz-Kwan Yiu, Kai-Hang Tse, Hung-Fat Wilkinson, Ian B. Chan, Yap-Hang affil: https://ror.org/02zhqgq86 Department of Medicine, School of Clinical Medicine, The University of Hong Kong, K1927C, Queen Mary Hospital, 102 Pokfulam Road, Pok Fu Lam, Hong Kong SAR, China sug: subj: Cardiovascular Diseases Prevention and Control Colchicine Therapeutic Use Major Adverse Cardiac Events Prevention and Control Colchicine Adverse Effects Human Male Female Systematic Review PubMed Embase Cochrane Library Descriptive Statistics Checklists Meta Analysis Data Analysis Software Odds Ratio Confidence Intervals C-Reactive Protein Funding Source Male Female ab: Background: Colchicine has been incorporated into major clinical guidelines for the secondary prevention of cardiovascular disease (CVD). However, recent randomized trials have presented contradictory results. Objective: We aimed to synthesize the current evidence on colchicine in secondary CVD protection, using a cumulative-dose approach. Methods: We conducted a meta-analysis incorporating all randomized controlled trials (RCTs) globally. RCTs directly comparing colchicine versus placebo/standard care for the secondary prevention of cerebrovascular or coronary vascular disease were included. Odds ratios (OR) were derived for the primary outcome, defined as the prospective occurrence of major adverse cardiovascular events (MACE). Secondary outcomes included mortality, individual components of MACE, C-reactive protein, and adverse effects. Results: In total, 14 RCTs including 31,397 participants were included. Colchicine significantly reduced MACE (OR 0.80; 95% confidence interval [CI] 0.68–0.94) in both acute atherothrombotic CVD and all CVD (OR 0.72; 95% CI 0.60–0.86) and resulted in significant prospective reductions in C-reactive protein. The threshold effect was apparent, with a protective benefit of colchicine against MACE at higher cumulative exposure ≥ 90 mg-days (OR 0.66; 95% CI 0.52–0.84). Colchicine resulted in no differences in cardiovascular or non-cardiovascular mortality. Conclusions: Colchicine significantly reduces MACE in both acute atherothrombotic and all CVD across multiple ethnicities, with a threshold protective effect that clinically corresponds to treatment with 0.5 mg daily for at least 6 months. Importantly, there was no signal of increased all-cause mortality. Registration: PROSPERO identifier no. CRD420251003142. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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