Challenges of enrolling participants with alcohol and opioid use disorders in the emergency department for clinical trials of ketamine: The experience from two randomized controlled trials.
Application of psychedelics including ketamine may be important adjuncts in the treatment of alcohol and opioid use disorders. Most patients with alcohol or opioid use disorder (AUD/OUD) may present to the emergency department (ED) seeking care both for substance use and associated complaints. Under...
| Publicado en: | General Hospital Psychiatry Vol. 98; pp. 159 - 165 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Elsevier B.V.
Jan2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=190794018&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 190794018 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01638343 JFH jtl: General Hospital Psychiatry issn: 01638343 maglogo: N pubinfo: dt: Jan2026 vid: 98 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 190794018 10.1016/j.genhosppsych.2025.12.019 190794018 ppf: 159 ppct: 6 formats: tig: atl: Challenges of enrolling participants with alcohol and opioid use disorders in the emergency department for clinical trials of ketamine: The experience from two randomized controlled trials. aug: au: Chai, P.R. Lee, E. Hasdianda, M.A. Bianchi, M. Campbell, D. Goldfine, C. Suzuki, J. affil: Department of Emergency Medicine, Brigham and Women's Hospital, United States of America sug: subj: Emergency Service Alcoholism Drug Therapy Narcotics Substance Use Disorders Drug Therapy Ketamine Therapeutic Use Drug Efficacy Evaluation Randomized Controlled Trials Double-Blind Studies Research Subject Recruitment Ketamine Administration and Dosage Eligibility Determination Consent (Research) After Care ab: Application of psychedelics including ketamine may be important adjuncts in the treatment of alcohol and opioid use disorders. Most patients with alcohol or opioid use disorder (AUD/OUD) may present to the emergency department (ED) seeking care both for substance use and associated complaints. Understanding safety and preliminary efficacy of ketamine and other psychedelics to improve the care and potentially facilitate linkage to long term care for AUD/OUD in the ED is of high importance. Here, we describe our experience conducting rigorous double blind placebo controlled trials to evaluate safety of ketamine in the ED for AUD/OUD and the challenges in conducting this research among this important population. We conducted two studies to evaluate the safety of a single dose ketamine infusion for individuals seeking detox with AUD and those seeking psychiatric care who had OUD. Studies were conducted at an urban community and academic ED with variable pharmacy capabilities. Over the study period study 1 (AUD) screened N = 180 individuals for the study of which N = 3 were preliminarily eligible. None were able to pass full eligibility criteria resulting in no enrollments. Study 2 (OUD) screened N = 234 ED visits were screen of which N = 8 were eligible and N = 4 consented. All four participants were successfully randomized and treated with ketamine or placebo. We were unable to conduct follow up in any of the participants. Enrollment of ED patients with AUD/OUD for ketamine trials in the ED is difficult and fraught with multiple challenges. Even with enrollment in the ED, follow up can be a significant challenge. This reinforces the need to consider innovative strategies to conduct ketamine and other psychedelic related trials among ED patients with AUD/OUD. • Patients with alcohol and opioid use disorder may utilize the emergency department to seek care for their substance use. • Ketamine infusions in the ED may improve alcohol/opioid use and improve linkage to care. • Conducting rigorous safety research on Ketamine in the ED among those with AUD/OUD is challenging. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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