Association Between Irbesartan and Erectile Dysfunction: A Comprehensive Analysis Incorporating Real-World Pharmacovigilance and Mendelian Randomization.
Background: Irbesartan is widely used for hypertension management, but its relationship with erectile dysfunction (ED) is unclear. This study combines real-world data from the FAERS database with Mendelian randomization to explore this potential association. Methods: We conducted multiple pharmacovi...
| Publicado en: | Hospital Pharmacy Vol. 61; no. 1; pp. 59 - 68 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Feb2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=190799068&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 190799068 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00185787 1WYH jtl: Hospital Pharmacy issn: 00185787 maglogo: Y pubinfo: dt: Feb2026 vid: 61 iid: 1 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 190799068 188693623 190799068 190799068 10.1177/00185787251348650 190799068 ppf: 59 ppct: 9 formats: tig: atl: Association Between Irbesartan and Erectile Dysfunction: A Comprehensive Analysis Incorporating Real-World Pharmacovigilance and Mendelian Randomization. aug: au: Chen, Kaiqin Cheng, Rui Guo, Jian Zhang, Shangming affil: Xiang'an Hospital of Xiamen University, Xia Men, Fu Jian, China sug: subj: Mendelian Randomization Pharmacovigilance Erectile Dysfunction Chemically Induced Irbesartan Adverse Effects Irbesartan Pharmacodynamics Erectile Dysfunction Risk Factors Adverse Drug Event Databases, Health Evaluation Risk Assessment Human Male Adolescence Adult Middle Age Aged Hypertension Drug Therapy Odds Ratio Probability Neural Networks (Computer) Confidence Intervals Genetic Screening UK Biobank Descriptive Statistics Data Analysis Software Irbesartan Administration and Dosage Nervous System Diseases Chemically Induced Gastrointestinal Diseases Chemically Induced Metabolic Diseases Chemically Induced Genital Diseases, Male Chemically Induced Chi Square Test Data Analysis, Statistical Age Factors Funding Source Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male ab: Background: Irbesartan is widely used for hypertension management, but its relationship with erectile dysfunction (ED) is unclear. This study combines real-world data from the FAERS database with Mendelian randomization to explore this potential association. Methods: We conducted multiple pharmacovigilance analyses, including odds ratio (ROR), proportional reporting ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Gamma-Poisson Shrinker (GPS), to assess the association between irbesartan and ED. Additionally, Mendelian randomization was applied to investigate the causal relationship. Results: The pharmacovigilance analyses indicated a significant association between irbesartan and ED: ROR = 3.38 (95% CI: 2.36-4.84), PRR = 3.38 (95% CI: 2.36-4.83), IC = 1.75 (95% CI: 1.13-2.17), and EBGM = 3.37 (95% CI: 2.36-4.83). Mendelian randomization analysis also showed a significant correlation using the inverse variance weighting method (P =.01, β = 10.06, SE = 3.91), with other methods yielding consistent directional results. Conclusion: Our study reveals a significant association and potential causal link between irbesartan use and ED. These findings highlight the need to consider ED as a possible adverse effect when prescribing irbesartan. Further research and clinical monitoring are essential to understand the underlying mechanisms and develop strategies to mitigate this side effect. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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