Does health-related quality of life change across pregnancy trimesters? A systematic review and meta-analysis.

Purpose: This study aimed to systematically review and synthesize existing evidence on health-related quality of life (HRQOL) across pregnancy trimesters, identifying consistent temporal patterns and domain-specific trajectories in maternal well-being. Methods: Five databases (PubMed, EMBASE, CINAHL...

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Publicado en:Women's Health Nursing Vol. 31; no. 4; pp. 320 - 335
Autores principales: Shin, Hyunjeong, Cho, Inhae, Kim, Sung-Jin
Formato: meta analysis research systematic review tables/charts Journal Article
Publicado: Korean Academy of Women's Health Nursing Dec2025
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Dec2025
      vid: 31
      iid: 4
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      pub: Korean Academy of Women's Health Nursing
      place: Seoul, <Blank>
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        190872030
        190872030
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        10.4069/whn.2025.12.02.1
        190872030
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        atl: Does health-related quality of life change across pregnancy trimesters? A systematic review and meta-analysis.
      aug:
        au:
          Shin, Hyunjeong
          Cho, Inhae
          Kim, Sung-Jin
        affil: Department of Nursing, Korea University, Seoul, Korea
      sug:
        subj:
          Pregnancy Trimesters Psychosocial Factors
          Quality of Life Psychosocial Factors
          Human
          Systematic Review
          Meta Analysis
          Pregnancy
          Female
          PubMed
          Embase
          CINAHL Database
          Checklists
          Questionnaires
          Expectant Mothers Psychosocial Factors
          Mental Health
          Physical Fitness
          Psychometrics
          Treatment Effect Heterogeneity
          Fetal Development
          Ethnological Research
          Funding Source
          Female
      ab: Purpose: This study aimed to systematically review and synthesize existing evidence on health-related quality of life (HRQOL) across pregnancy trimesters, identifying consistent temporal patterns and domain-specific trajectories in maternal well-being. Methods: Five databases (PubMed, EMBASE, CINAHL Complete, APA PsycArticles, and RISS) were searched to retrieve English and Korean articles published between January 2001 and May 2023. Two reviewers independently screened and appraised studies using the Joanna Briggs Institute critical appraisal tools. A meta-analysis was performed using STATA 17.0 (StataCorp LLC.), with pairwise comparisons of standardized mean differences used to evaluate trimester-specific variations. Subgroup analyses were performed based on measurement instruments and HRQOL domains (mental vs. physical health). Results: A total of 13 studies involving 4,809 pregnant participants were included. Overall HRQOL showed no significant differences between the first and second trimesters or between the first and third trimesters. However, HRQOL scores in the third trimester were significantly lower than those in the second trimester (Hedges' g=-0.42; 95% confidence interval, -0.77 to -0.06). Subgroup analyses revealed that the choice of measurement instruments significantly influenced the detection of changes in HRQOL. Mental health scores improved in mid-pregnancy and remained relatively stable, whereas physical health scores declined after mid-pregnancy, reaching their lowest point in the third trimester. Conclusion: HRQOL during pregnancy follows distinct temporal patterns, emphasizing the need for trimester-specific maternal care strategies. Early pregnancy may require greater emphasis on mental health support, while late pregnancy may benefit from interventions targeting physical discomfort and functional limitations.
      pubtype: Academic Journal
      doctype:
        meta analysis
        research
        systematic review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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