Exhaled Carbon Monoxide Indicates Persistent Subgingival Dysbiosis After Periodontal Therapy.
Aim: To investigate whether exhaled carbon monoxide (CO) is dose‐dependently associated with subgingival polymicrobial clusters before and after non‐surgical periodontal therapy. Material and Methods: We followed 163 adults with periodontitis, measuring CO before and at 2, 14 and 26 months after the...
| Publicado en: | Journal of Clinical Periodontology Vol. 53; no. 2; pp. 170 - 179 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Feb2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=190911524&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 190911524 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03036979 8E3 jtl: Journal of Clinical Periodontology issn: 03036979 maglogo: Y pubinfo: dt: Feb2026 vid: 53 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 190911524 188697590 190911524 190911524 10.1111/jcpe.70053 190911524 ppf: 170 ppct: 9 formats: tig: atl: Exhaled Carbon Monoxide Indicates Persistent Subgingival Dysbiosis After Periodontal Therapy. aug: au: Koehlen, Sophie Harks, Inga Matern, Johannes Prior, Karola Eickholz, Peter Lorenz, Katrin Kim, Ti‐Sun Kocher, Thomas Meyle, Jörg Kaner, Doğan Jockel‐Schneider, Yvonne Harmsen, Dag Ehmke, Benjamin Kleine Bardenhorst, Sven Hagenfeld, Daniel affil: Department of Periodontology and Operative Dentistry, Münster University Hospital, Münster, Germany sug: subj: Expiration Carbon Monoxide Gingiva Microbiology Periodontitis Therapy Smoking Complications Human Dental Plaque Sequence Analysis Regression Sensitivity and Specificity Confidence Intervals Descriptive Statistics Academic Medical Centers Secondary Analysis Young Adult Adult Middle Age Aged Oral Hygiene Polymerase Chain Reaction Data Analysis Software Wilcoxon Rank Sum Test Analysis of Variance Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years ab: Aim: To investigate whether exhaled carbon monoxide (CO) is dose‐dependently associated with subgingival polymicrobial clusters before and after non‐surgical periodontal therapy. Material and Methods: We followed 163 adults with periodontitis, measuring CO before and at 2, 14 and 26 months after therapy. Subgingival plaque samples were analysed using 16S rRNA gene sequencing. We applied topic models and regression analysis, adjusted for age, sex, treatment group, pocket probing depth and plaque levels. Results: Smokers had generally higher mean CO levels at every visit and showed significant declines at 14 and 26 months after therapy (p < 0.01). Before therapy, CO was not associated with dysbiosis; after therapy, higher levels were positively associated. In sensitivity analyses, self‐reported smoking status explained more variance in dysbiosis than CO alone, with only marginal gains when both were combined. Among smokers, a distinct polymicrobial cluster dominated by Fusobacterium and Prevotella increased with higher exhaled CO. Every 10 parts per million increase in CO was associated with an estimated 16% increase in cluster abundance (95% confidence interval: 8%–26%). Conclusion: Exhaled CO may help monitor persistent dysbiosis and select an anaerobe‐dominated subgingival community after periodontal therapy among smokers. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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