Profiling the HIV Pre-exposure Prophylaxis (PrEP) Cascade in Japan: A Latent Class Analysis of a Nationwide Cross-Sectional Study.
To understand opportunities for improving pre-exposure prophylaxis (PrEP) uptake, this study constructed a PrEP cascade and examined subgroup profiles associated with transitions along the cascade among gay, bisexual, and other men who have sex with men (gbMSM) in Japan. An online cross-sectional su...
| Publicado en: | AIDS & Behavior Vol. 30; no. 1; pp. 142 - 151 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=190984208&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 190984208 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10907165 G1T jtl: AIDS & Behavior issn: 10907165 maglogo: N pubinfo: dt: Jan2026 vid: 30 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 190984208 187301856 190984208 190984208 10.1007/s10461-025-04854-0 190984208 ppf: 142 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Profiling the HIV Pre-exposure Prophylaxis (PrEP) Cascade in Japan: A Latent Class Analysis of a Nationwide Cross-Sectional Study. aug: au: Miwa, Takeshi Strong, Carol Ku, Stephane Wen-Wei Li, Chia-Wen Huang, Poyao Wu, Huei-Jiuan Yamaguchi, Masazumi Ikushima, Yuzuru affil: https://ror.org/01b8kcc49 Department of Public Health, College of Medicine, National Cheng Kung University, 8F-8068, No. 138, ShengLi Rd., North Dist., 704, Tainan, Taiwan sug: subj: HIV Infections Prevention and Control Pre-Exposure Prophylaxis Gay Persons Bisexual Persons Men Who Have Sex With Men Human Japan Female Male Adult Cross Sectional Studies Surveys Sociodemographic Factors Gender Identity Sexual Orientation Geographic Factors Sexual Behavior Condoms Maximum Likelihood Logistic Regression Structural Equation Modeling Data Analysis Software Descriptive Statistics Funding Source Adult: 19-44 years Female Male ab: To understand opportunities for improving pre-exposure prophylaxis (PrEP) uptake, this study constructed a PrEP cascade and examined subgroup profiles associated with transitions along the cascade among gay, bisexual, and other men who have sex with men (gbMSM) in Japan. An online cross-sectional survey was conducted from February to March 2021. The four-step PrEP cascade included awareness, willingness, initiation, and regimen use. Latent class analysis (LCA) identified participant subgroups, and logistic regression examined associations with the most significant drop-off in the cascade. Among 5,831 cisgender gbMSM not living with HIV (median age: 38 years), 52.6% were aware of PrEP, 76.4% of whom were willing to use it. However, only 20.5% of those willing had initiated PrEP—the largest decline in the cascade. Among those who initiated, 43.8% were on a daily regimen. LCA identified four subgroups: (i) Sexual Adventurers (32.1%)—high sexual activity and strong HIV community ties; (ii) Reserved Bystanders (26.7%)—low engagement with the HIV community and sexual health services; (iii) Positive Allies (24.6%)—strong HIV community ties and comfort discussing sexual health; and (iv) Young Explorers (16.7%)—younger, moderately sexually active, with limited HIV community ties. Compared to Reserved Bystanders, Sexual Adventurers (OR 5.27, 95% CI 3.91–7.10) and Positive Allies (OR 1.60, 95% CI 1.14–2.26) had significantly higher odds of PrEP initiation. Despite increasing acceptability, barriers to PrEP uptake persist. Targeted interventions are needed to address subgroup-specific challenges—particularly for younger gbMSM and those with limited access to HIV community networks and sexual health services. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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