Expression of GLUT-1 and SGLT-2 in the Chorioretina of Streptozotocin-induced Diabetic Rats After Administration of Empagliflozin.
Purpose: To assess the effect of empagliflozin on the expression of SGLT-2 and GLUT-1 in the chorioretina of streptozotocin-induced diabetic rats. Methods: An in vivo experimental study was performed on Wistar rats. After a 2-week adaptation period, the rats were allocated to one of four groups. The...
| Publicado en: | Journal of Ophthalmic & Vision Research Vol. 20; pp. 1 - 11 |
|---|---|
| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Knowledge E DMCC
2025
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=190994237&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 190994237 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20082010 AY5S jtl: Journal of Ophthalmic & Vision Research issn: 20082010 maglogo: N pubinfo: dt: 2025 vid: 20 pid: 35682 pub: Knowledge E DMCC artinfo: ui: 190994237 190994237 190994237 10.18502/jovr.v20.15231 190994237 ppf: 1 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Expression of GLUT-1 and SGLT-2 in the Chorioretina of Streptozotocin-induced Diabetic Rats After Administration of Empagliflozin. aug: au: Zaini, Lia Meuthia Kartasasmita, Arief S Gondhowiardjo, Tjahjono D Syukri, Maimun Lesmana, Ronny affil: Faculty of Medicine, Department of Medical Education, Syiah Kuala University, Banda Aceh, Indonesia sug: subj: Diabetes Mellitus, Type 1 Chemically Induced Plant Extracts Adverse Effects Diabetes Mellitus, Type 1 Drug Therapy Empagliflozin Therapeutic Use Empagliflozin Administration and Dosage Gene Expression Drug Effects Signal Transduction Drug Effects Animal Studies Rats Descriptive Statistics Data Analysis Software Analysis of Variance Confidence Intervals In Vivo Studies Experimental Studies Blotting, Western Indonesia ab: Purpose: To assess the effect of empagliflozin on the expression of SGLT-2 and GLUT-1 in the chorioretina of streptozotocin-induced diabetic rats. Methods: An in vivo experimental study was performed on Wistar rats. After a 2-week adaptation period, the rats were allocated to one of four groups. The group allocations were as follows: (K1) negative control (no intervention); (K2) positive control injected with streptozotocin (STZ) without treatment; (K3) positive control injected with STZ and treated with metformin; and (K4) positive control injected with STZ and treated with empagliflozin. SGLT-2 and GLUT-1 expressions were examined using the Western blot technique. Results: SGLT-2 was expressed in the chorioretinal tissue of all groups; administration of SGLT-2 inhibitors could suppress its expression. The average band thickness indicated that SGLT-2 expression was higher in diabetic rats compared to rats with normal sugar levels. GLUT-1 expression was noticed in all groups based on the chorioretinal examination. It did not change in the metformin group, whereas the empagliflozin group showed a significant decrease in the GLUT-1 expression. Conclusion: Both metformin and empagliflozin suppress the expression of SGLT-2 and GLUT-1 in the chorioretina of diabetic rats. In comparison, empagliflozin seems to be more potent in reducing this expression. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|