| Sumario: | Purpose: To evaluate the influence of preoperative ocular and systemic variables on intraocular pressure (IOP) change following phacoemulsification cataract extraction with intraocular lens (CEIOL) implantation in eyes without glaucoma. Methods: This retrospective cohort study included adults who underwent standalone CEIOL at a single academic center between 2017 and 2020. Preoperative demographic, ocular, and systemic health data were extracted from electronic health records using an informatics-based approach and validated by chart review. Eyes with glaucoma or other preoperative ocular conditions known to affect IOP were excluded. Postoperative IOP data were collected for up to 2 years and censored at the time of any subsequent diagnosis or treatment likely to influence IOP. A linear mixed-effects model was used to assess associations between IOP change and preoperative ocular (e.g., IOP, axial length, central corneal thickness) and systemic variables (e.g., diabetes, body mass index [BMI], smoking status), accounting for inter-eye correlation. Results: A total of 1992 eyes from 1755 patients were included. Higher preoperative IOP (β = –0.563, P < 0.001) and female gender (β = –0.229, P = 0.005) predicted greater postoperative IOP reduction. Longer axial length (β = 0.201, P < 0.001), diabetes mellitus (β = 0.291, P = 0.019), thicker cornea (β = 0.008, P < 0.001), and higher BMI (β = 0.022, P = 0.005) were associated with a relative increase in postoperative IOP. Conclusion: Both ocular and systemic variables significantly influenced postoperative IOP change following CEIOL in non-glaucomatous eyes. Understanding these associations may improve clinical decision-making and help tailor IOP-related counseling for patients undergoing cataract surgery.
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