Analyzing the Placebo Response and Identifying Influential Factors in Oral Medication Trials for Acute-Phase Schizophrenia.
Background and Hypothesis This study aims to develop a placebo response and dropout rate model for acute-phase schizophrenia medication trials and assess factors affecting this response to inform future trial design. Study Design We conducted a literature update using a comprehensive meta-analysis o...
| Publicado en: | Schizophrenia Bulletin Vol. 52; no. 1; pp. 1 - 12 |
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| Autores principales: | , , , , , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Jan2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191017130&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191017130 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 05867614 2CZ jtl: Schizophrenia Bulletin issn: 05867614 maglogo: N pubinfo: dt: Jan2026 vid: 52 iid: 1 pid: 622 pub: Oxford University Press / USA artinfo: ui: 191017130 191017130 191017130 10.1093/schbul/sbaf013 191017130 ppf: 1 ppct: 11 formats: tig: atl: Analyzing the Placebo Response and Identifying Influential Factors in Oral Medication Trials for Acute-Phase Schizophrenia. aug: au: Ren, Jiyuan Zhang, Lei Xu, Ling Lv, Yinghua Huang, Jihan Feng, Yulin Guo, Haoyang Wang, Yexuan Yang, Juan Zheng, Qingshan affil: Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China sug: subj: Schizophrenia Administration, Oral Clinical Trials Research Subjects Psychosocial Factors Research Dropouts Evaluation Prediction Models Evaluation Human Adult Middle Age Male Female Meta Analysis Funding Source Placebos Scales Symptom Burden Severity of Illness Evaluation Aging Body Weight African Americans Sex Factors Psychopathology Patient Participation Psychosocial Factors Descriptive Statistics Data Analysis Software Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background and Hypothesis This study aims to develop a placebo response and dropout rate model for acute-phase schizophrenia medication trials and assess factors affecting this response to inform future trial design. Study Design We conducted a literature update using a comprehensive meta-analysis of schizophrenia medication trials, focusing on oral placebo-controlled studies. We modeled the placebo response on the Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impressions-Severity of Illness (CGI-S) scale over time and analyzed dropout rates. Influential factors were explored using covariate models and subgroup analyses. Study Results Aggregate-level data from 48 publications were analyzed. The placebo response reached a plateau at different weeks for PANSS and CGI-S scale scores. The lower the baseline of PANSS total score, older age, heavier body weight, a higher proportion of male or Black patients, smaller sample sizes, single-country trials, older studies, and the use of the Last Observation Carried Forward imputation were associated with a lower placebo response. Maximum response of PANSS Total score and gender significantly influenced dropout rates. Conclusions We present a model predicting placebo response in schizophrenia trials, offering insights into the impact of various trial characteristics, aiding in the design and interpretation of future clinical studies. pubtype: Academic Journal doctype: equations & formulas meta analysis research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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