Effects of ABC transporter polymorphism on the pharmacokinetics of pentoxifylline and its active metabolites in healthy Chinese subjects.
Purpose: The objective of this study was to evaluate the influence of genetic polymorphisms in drug transporters on the pharmacokinetics of pentoxifylline (PTX) and its key active metabolites in a healthy Chinese population. Subjects and methods: Forty-six healthy Chinese volunteers were enrolled an...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 82; no. 2; pp. 1 - 11 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191036636&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191036636 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Feb2026 vid: 82 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 191036636 10.1007/s00228-026-03993-0 191036636 ppf: 1 ppct: 10 formats: tig: atl: Effects of ABC transporter polymorphism on the pharmacokinetics of pentoxifylline and its active metabolites in healthy Chinese subjects. aug: au: Guo, Lingfang Sun, Xue Qiu, Bo Bai, Wanjun Du, Yabin Song, Haojing affil: https://ror.org/01nv7k942 Department of Pharmacy, Hebei General Hospital, Hebei Key Laboratory of Clinical Pharmacy, 050051, Shijiazhuang, China sug: ab: Purpose: The objective of this study was to evaluate the influence of genetic polymorphisms in drug transporters on the pharmacokinetics of pentoxifylline (PTX) and its key active metabolites in a healthy Chinese population. Subjects and methods: Forty-six healthy Chinese volunteers were enrolled and took oral administration of 400 mg pentoxifylline. Plasma concentrations of PTX and its active metabolites (M1 and M5) were determined using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Genotyping of ABCB1 (3435C>T, 1236C>T, 2677G>T/A), ABCG2 (421C>A, 34G>A), and ABCC2 (-24C>T, 1249G>A, 3972C>T) was performed using the SnapShot technique. Results: Under fasting conditions, subjects carrying the ABCB1 3435C/T genotype demonstrated a significantly lower AUC (P < 0.05, Bonferroni-corrected) and a higher CL/F (P < 0.01, Bonferroni-corrected) of PTX compared to those carrying the ABCB1 3435C/C genotype. Furthermore, carriers of the ABCB1 3435C/T genotype exhibited a significantly higher metabolic conversion rate to M5 (P < 0.05, Bonferroni-corrected). Similarly, subjects with the ABCB1 2677(A/A+A/T) genotypes also showed a higher M5 conversion rate (P < 0.05, Bonferroni-corrected). Conclusion: The ABCB1 3435C>T and 2677G>T/A polymorphisms are associated with variations in the pharmacokinetics of PTX and its active metabolites. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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