Single‐Center Epidemiological Analysis of Malignant Transformation With Skin Ulcers in Outpatients.
Investigate the epidemiological characteristics of outpatients initially diagnosed with skin ulcers who were ultimately confirmed to have cutaneous malignant tumours, and provide a diagnostic and therapeutic basis for the occurrence of secondary diseases in chronic wounds. We conducted a retrospecti...
| Publicado en: | International Wound Journal Vol. 23; no. 1; pp. 1 - 7 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jan2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191104912&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191104912 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17424801 1725 jtl: International Wound Journal issn: 17424801 maglogo: Y pubinfo: dt: Jan2026 vid: 23 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 191104912 191104912 191104912 10.1111/iwj.70812 191104912 ppf: 1 ppct: 6 formats: tig: atl: Single‐Center Epidemiological Analysis of Malignant Transformation With Skin Ulcers in Outpatients. aug: au: Kong, Yaoyao Wang, Haixia Cao, Nan Huai, Pengcheng Wang, Zhenzhen Zuo, Chaoqi Wang, Xueqing Wu, Yilei Liu, Yongxia Chen, Shengli Liu, Hong Zhang, Guangliang affil: Dermatology Hospital of Shandong First Medical University, Jinan Shandong,, China sug: subj: Skin Ulcer Physiopathology Cell Transformation, Neoplastic Epidemiology Skin Neoplasms Epidemiology Outpatient Service Skin Neoplasms Diagnosis Early Detection of Cancer Human Funding Source China Male Female Adult Middle Age Aged Aged, 80 and Over Retrospective Design Record Review Vasculitis Dermatitis Folliculitis Pyoderma Gangrenosum Histological Techniques Biopsy Descriptive Statistics Data Analysis Software Chi Square Test Fisher's Exact Test Multiple Logistic Regression Two-Tailed Test Carcinoma, Squamous Cell Carcinoma, Basal Cell Bowen Technique Mycosis Fungoides Adenocarcinoma Neoplasm Metastasis Multivariate Analysis Odds Ratio Confidence Intervals Age Factors Head and Neck Neoplasms Sex Factors Disease Duration Outpatients Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Investigate the epidemiological characteristics of outpatients initially diagnosed with skin ulcers who were ultimately confirmed to have cutaneous malignant tumours, and provide a diagnostic and therapeutic basis for the occurrence of secondary diseases in chronic wounds. We conducted a retrospective study analysing clinical data from patients initially diagnosed with skin ulcers at our hospital between July 2021 and February 2025, and analysed the epidemiological characteristics of malignant transformation in these ulcer cases. Among 128 patients initially diagnosed with skin ulcers, 16 cases (12.5%) were confirmed with cutaneous malignancies. The malignant group had a significantly higher mean age (69.44 ± 11.30 years) compared to the non‐malignant group (58.39 ± 17.88 years; t = 5.752, p = 0.01). The distribution of lesion sites differed significantly between the malignant and non‐malignant groups (χ2 = 30.498, p < 0.01). In the malignant group, the head and neck (41.2%) and trunk & extremities (41.2%) were the predominant sites. The most common malignancy was squamous cell carcinoma (SCC). The trunk & extremities was the most frequent site (62.5%). The second was basal cell carcinoma, which mainly occurs in the head and neck (80.0%). The mean duration of ulceration was 4.5 years. The primary treatment modality was surgical excision (11 cases, 68.8%). Approximately one‐seventh of skin ulcer cases were confirmed as cutaneous malignancies. This finding underscores the significance of skin ulcers as potential malignant lesions, highlighting the need for clinicians to maintain a high index of suspicion and promptly perform histopathological examinations to improve early detection rates of skin cancers. Summary: This study confirms that 12.5% of chronic skin ulcers may transform into malignancies (primarily squamous cell carcinoma/basal cell carcinoma.), with a significant predominance of elderly individuals.Clinicians must maintain heightened vigilance for malignant transformation in non‐healing, recurrently infected, or morphologically atypical ulcers, prioritizing prompt skin biopsy to avoid diagnostic delays. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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