Acute‐Phase Interventions and Clinical Implementation Challenges for Hospital‐Associated Sarcopenia: A Narrative Review of a Multifaceted Approach to a Preventable Condition.

Hospital‐associated sarcopenia (HAS) is a preventable and reversible condition characterized by rapid muscle loss during hospitalization. Although its prevalence is higher than that of age‐related sarcopenia, the clinical recognition and structured management of this condition remain limited. In thi...

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Publicado en:Geriatrics & Gerontology International Vol. 26; no. 1; pp. 1 - 12
Autores principales: Yamamoto, Yoshinori, Ogawa, Masato, Okamoto, Takayuki, Tsuboi, Marika, Momosaki, Ryo
Formato: review tables/charts Journal Article
Publicado: Wiley-Blackwell Jan2026
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jan2026
      vid: 26
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        atl: Acute‐Phase Interventions and Clinical Implementation Challenges for Hospital‐Associated Sarcopenia: A Narrative Review of a Multifaceted Approach to a Preventable Condition.
      aug:
        au:
          Yamamoto, Yoshinori
          Ogawa, Masato
          Okamoto, Takayuki
          Tsuboi, Marika
          Momosaki, Ryo
        affil: Department of Rehabilitation Medicine, Mie University Graduate School of Medicine, Tsu Mie,, Japan
      sug:
        subj:
          Sarcopenia Prevention and Control
          Iatrogenic Disease Prevention and Control
          Early Ambulation Methods
          Acute Care Methods
          Preventive Health Care Methods
          Hospitalization of Older Persons
          Aged
          Nutritional Support
          Stretching
          Resistance Training
          Muscle Strengthening
          Inpatients
          Multidisciplinary Care Team
          Implementation Science
          Length of Stay
          Hospital Programs
          Physical Activity
          Early Intervention
          Early Diagnosis
          Physical Therapy
          Occupational Therapy
          Aged: 65+ years
      ab: Hospital‐associated sarcopenia (HAS) is a preventable and reversible condition characterized by rapid muscle loss during hospitalization. Although its prevalence is higher than that of age‐related sarcopenia, the clinical recognition and structured management of this condition remain limited. In this narrative review, the pathophysiology of HAS is synthesized, the effectiveness of acute‐phase interventions is evaluated, and the implementation challenges are examined to propose multifaceted strategies for optimizing treatment outcomes. The development of HAS involves a vicious cycle of activity limitation, inflammation, malnutrition, and iatrogenic stress. Initiating interventions within 48 h may aid in preserving muscle function and improving the patients' quality of life. However, protocol variability, inadequate patient stratification, fragile transitional care systems, and other challenges persist. The proposed solutions include modular protocols, electronic medical record‐integrated adaptive algorithms, and strengthened team coordination. To prevent HAS progression and improve patient‐centered outcomes, timely, structured multidisciplinary interventions in the acute phase are imperative. Standardized evaluations, scalable protocols, and sustainable post‐discharge systems are key to advancing the clinical implementation of HAS management strategies.
      pubtype: Academic Journal
      doctype:
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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