Histopathologic Progression of Autoimmune Atrophic Gastritis: A Retrospective Review of 180 Specimens From 32 Patients.
* Context.--Autoimmune atrophic gastritis (AIAG) is a chronic, immune-mediated inflammation restricted to the gastric body. Despite well-defined histologic features, the pathologic progression is still not fully understood. Objective.--To evaluate the pathologic progression of AIAG. Design.--AIAG ca...
| Publicado en: | Archives of Pathology & Laboratory Medicine Vol. 150; no. 1; pp. 81 - 88 |
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| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
College of American Pathologists
Jan2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191144601&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191144601 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00039985 1FS jtl: Archives of Pathology & Laboratory Medicine issn: 00039985 maglogo: N pubinfo: dt: Jan2026 vid: 150 iid: 1 pid: 2550 pub: College of American Pathologists place: Northfield, Illinois artinfo: ui: 191144601 191144601 191144601 10.5858/arpa.2025-0030-OA 191144601 ppf: 81 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Histopathologic Progression of Autoimmune Atrophic Gastritis: A Retrospective Review of 180 Specimens From 32 Patients. aug: au: Wang, Xi Jiao, Jingjing Huh, Won Jae Zhang, Xuchen affil: Department of Pathology, Yale University School of Medicine, New Haven, Connecticut sug: subj: Gastritis, Atrophic Pathology Autoimmune Diseases Pathology Disease Progression Human Biopsy Retrospective Design Nonexperimental Studies Record Review Male Female Adult Middle Age Aged Aged, 80 and Over Neuroendocrine Tumors Stomach Neoplasms Endoscopy, Gastrointestinal Adenocarcinoma Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: * Context.--Autoimmune atrophic gastritis (AIAG) is a chronic, immune-mediated inflammation restricted to the gastric body. Despite well-defined histologic features, the pathologic progression is still not fully understood. Objective.--To evaluate the pathologic progression of AIAG. Design.--AIAG cases with at least 2 follow-up biopsies were reviewed. Clinical data, including anemia and autoimmune antibody status, were collected. Gastric samples were analyzed to assess inflammation, atrophy, enterochromaffinlike cell hyperplasia, and the development of neuroendocrine tumors (NETs) or carcinoma. Results.--The cohort included 180 cases from 32 patients (21 females, 11 males), with an average follow-up of 6.8 years and 5.7 biopsies per patient. Inflammation, atrophy, and intestinal metaplasia remained stable in 59.4% (19 of 32), 78.1% (25 of 32), and 50% (16 of 32) of follow-up biopsies, respectively. Six patients had NETs in the AIAG index cases, with 5 experiencing recurrence after endoscopic excision. During follow-up, 6 additional patients developed NETs, half of whom had recurrence following endoscopic excision. The NETs were well differentiated with a Ki-67 index less than 3%. Two patients were initially diagnosed with adenocarcinoma in the background of AIAG, and 2 more developed adenocarcinoma during follow-up. No significant changes were observed in the antrum during follow-up, which consistently showed minimal to mild inflammation and reactive gastropathy. Conclusions.--Long-term follow-up indicates that AIAG is linked to the pathologic progression of NETs and gastric adenocarcinoma. The NETs arising in the background of AIAG are well differentiated and show no evidence of metastasis. These findings may provide guidance on optimal endoscopic surveillance intervals for patients with AIAG. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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