False Negative Thyroid Biopsy: A Case Report Highlighting the Importance of Ultrasound Evaluation.

Introduction: The increasing use of advanced imaging modalities has led to a growing number of Incidental thyroid nodules (ITNs). Although most ITNs are benign, dedicated evaluation with a thyroid ultrasound (US) is strongly recommended to assess malignancy risk with a dedicated. Case Presentation:...

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Publicado en:Clinical Medicine Insights: Case Reports Vol. 19; pp. 1 - 6
Autores principales: Reyes San Martin, Fernando, Chozet, Luis, Koops, Maureen, Cortes, Tiffany Marie
Formato: case study diagnostic images pictorial Journal Article
Publicado: Sage Publications Inc. 1/26/2026
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 1/26/2026
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      pub: Sage Publications Inc.
      place: Thousand Oaks, California
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        atl: False Negative Thyroid Biopsy: A Case Report Highlighting the Importance of Ultrasound Evaluation.
      aug:
        au:
          Reyes San Martin, Fernando
          Chozet, Luis
          Koops, Maureen
          Cortes, Tiffany Marie
        affil: Department of Endocrinology, UT Health San Antionio, TX, USA
      sug:
        subj:
          Thyroid Gland Ultrasonography
          Leukemia, Lymphocytic, Chronic Radiography
          Lymphoma, B-Cell Radiography
          Male
          Aged
          Fludeoxyglucose F 18 Diagnostic Use
          Positron-Emission Tomography
          Biopsy, Needle
          Immunohistochemistry
          Thyroid Neoplasms Radiography
          Thyroid Neoplasms Pathology
          Physical Examination
          Laboratories
          Multidisciplinary Care Team
          Flow Cytometry
          Aged: 65+ years
          Male
      ab: Introduction: The increasing use of advanced imaging modalities has led to a growing number of Incidental thyroid nodules (ITNs). Although most ITNs are benign, dedicated evaluation with a thyroid ultrasound (US) is strongly recommended to assess malignancy risk with a dedicated. Case Presentation: We report a case of a 66-year-old male with large fluorodeoxyglucose (FDG)-avid right thyroid mass identified incidentally on a positron emission tomography (PET) scan. Initial fine needle aspiration (FNA) suggested benign pathology. However, subsequent thyroid US demonstrated highly suspicious features concerning for lymphoma or sarcoma, prompting a core biopsy with flow cytometry and immunohistochemistry, which confirmed a diagnosis of small lymphocytic B-cell infiltrating the thyroid gland. Conclusion: This case underscores the diagnostic limitation of FNA in detecting thyroid lymphoma and highlights the critical role of thyroid US in identifying concerning features. When US findings are highly suspicious for lymphoma, additional diagnostic approaches – including core biopsy with flow cytometry and immunohistochemistry – are essential to ensure accurate diagnosis and appropriate management.
      pubtype: Academic Journal
      doctype:
        case study
        diagnostic images
        pictorial
        Journal Article
      ougenre: Article
    language: English
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