Assessing How Obesity Affects the Risk of Endometrial Cancer.
Obesity is a significant lifestyle factor that affects the development and outcomes of endometrial tumors. Excess body weight can disrupt hormonal balance and promote cellular mutations, increasing the risk of endometrial cancer. We developed a three-step stochastic model that incorporates clonal pr...
| Publicado en: | Nutrition & Cancer Vol. 78; no. 3; pp. 195 - 208 |
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| Autores principales: | , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191178554&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191178554 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2026 vid: 78 iid: 3 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 191178554 190271875 191178554 191178554 10.1080/01635581.2025.2598922 191178554 ppf: 195 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Assessing How Obesity Affects the Risk of Endometrial Cancer. aug: au: Nagah, Ahmed Liu, Xinge affil: School of Mathematics and Statistics, Central South University, Changsha, Hunan 410083, China sug: subj: Obesity Complications Endometrial Neoplasms Risk Factors Disease Progression Risk Factors Women Psychosocial Factors Risk Assessment Human Female United States Funding Source Models, Statistical Body Weight Mutation Premenopause Cell Movement Cell Line, Tumor Age Factors Centers for Disease Control and Prevention (U.S.) Disease Surveillance Endometrial Neoplasms Epidemiology Incidence Evaluation Descriptive Statistics Chi Square Test Female ab: Obesity is a significant lifestyle factor that affects the development and outcomes of endometrial tumors. Excess body weight can disrupt hormonal balance and promote cellular mutations, increasing the risk of endometrial cancer. We developed a three-step stochastic model that incorporates clonal proliferation at each stage to investigate how obesity affects cancer progression. The model was tested on two datasets: non-obesity-related cases from the SEER registry (2010–2020) and obesity-related cases in women from the CDC (2017–2021). Our results show that obesity mainly impacts the development of endometrial tumors by causing genetic mutations in women. The stochastic model indicates that fat increases the rates of both initial and later mutations. Body weight can affect the rate at which early intermediate cells multiply, especially in women who are still premenopausal. Understanding how these cellular changes happen is important for estimating an individual's risk of developing endometrial cancer. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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