Pediatric and adult point of view on the gut-kidney axis in CKD.
Chronic non-communicable diseases pose a significant global health challenge, with the human gut microbiota emerging as a key player in several (patho) physiological functions, including immunity, metabolic homeostasis, and inflammation. While dysbiosis, or imbalance in taxonomy and function of gut...
| Publicado en: | Pediatric Nephrology Vol. 41; no. 3; pp. 633 - 649 |
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| Autores principales: | , , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191207193&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191207193 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Mar2026 vid: 41 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 191207193 186436257 191207193 191207193 10.1007/s00467-025-06780-8 191207193 ppf: 633 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Pediatric and adult point of view on the gut-kidney axis in CKD. aug: au: Holle, Johannes Behrens, Felix Koppe, Laetitia affil: https://ror.org/001w7jn25 Department of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité – Universitätsmedizin Berlin, Berlin, Germany sug: subj: Kidney Failure, Chronic Gut Microbiota Physiology Kidney Physiology Gut Microbiota Physiology Kidney Physiology Pathologic Processes Individualized Medicine Inflammation Immunity Physiology Metabolism Physiology Uremic Toxins Blood Fatty Acids, Volatile Metabolism Probiotics Therapeutic Use Prebiotics Therapeutic Use Synbiotics Therapeutic Use Fecal Microbiota Transplantation Enzyme Inhibitors Therapeutic Use Child Adult Child: 6-12 years Adult: 19-44 years ab: Chronic non-communicable diseases pose a significant global health challenge, with the human gut microbiota emerging as a key player in several (patho) physiological functions, including immunity, metabolic homeostasis, and inflammation. While dysbiosis, or imbalance in taxonomy and function of gut microbiota, has been implicated in chronic kidney disease (CKD), whether it is a cause or consequence of the disease remains controversial. Understanding the gut microbiota's role in CKD pathogenesis is essential for developing novel therapeutic interventions. CKD in children presents unique opportunities for studying disease-specific mechanisms due to the absence of comorbidities typically seen in adults, such as diabetes, obesity, and hypertension, although few studies exist. On the other hand, unlike the relatively stable gut microbiota of healthy adults, the infant's microbiome undergoes significant development and maturation during the early years of life. Integrating knowledge from both pediatric and adult populations may provide a comprehensive understanding of gut microbiota dysbiosis in CKD. This review aims to provide an overview of the gut microbiota's development in healthy individuals and CKD patients and discusses how these findings can inform personalized treatment approaches to CKD. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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