Research on the Side Effects of Intravenous Methylprednisolone in Hospitalized Pediatric Patients With Neurological Diseases.
Background: High‐dose methylprednisolone pulse therapy is being increasingly used in the treatment of neurological disorders; however, there is still a lack of studies on the side effects associated with this treatment regimen in the context of neurological diseases. Methods: We conducted a retrospe...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 2026; pp. 1 - 9 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
1/29/2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191211553&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191211553 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: 1/29/2026 vid: 2026 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 191211553 191211553 191211553 10.1155/jcpt/5576276 191211553 ppf: 1 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Research on the Side Effects of Intravenous Methylprednisolone in Hospitalized Pediatric Patients With Neurological Diseases. aug: au: Wang, Baotian Wang, Shunxin Yang, Li Jiang, Junhong Hua, Ran Tang, Jiulai Wu, De Xu, Yue affil: Department of Pediatrics, , The First Affiliated Hospital of Anhui Medical University, , Hefei, Anhui, China, ahmu.edu.cn sug: subj: Methylprednisolone Administration and Dosage Methylprednisolone Adverse Effects Administration, Intravenous Child, Hospitalized Pediatrics Nervous System Diseases Drug Therapy Adverse Drug Event Professional Practice, Evidence-Based Human Male Female Retrospective Design Electronic Health Records Nursing Records Child, Preschool Child Descriptive Statistics Data Analysis Software Chi Square Test T-Tests Pearson's Correlation Coefficient Logistic Regression Odds Ratio Confidence Intervals Heart Rate Bradycardia Leukocyte Count Age Factors Hospitalization Multivariate Analysis Univariate Statistics Child, Preschool: 2-5 years Child: 6-12 years Male Female ab: Background: High‐dose methylprednisolone pulse therapy is being increasingly used in the treatment of neurological disorders; however, there is still a lack of studies on the side effects associated with this treatment regimen in the context of neurological diseases. Methods: We conducted a retrospective analysis of patients who received high‐dose methylprednisolone pulse therapy for neurological diseases at our hospital between January 2021 and August 2025. The clinical manifestations, auxiliary examinations, and outcomes were documented. We summarized and compared the clinical features of side effects associated with high‐dose methylprednisolone pulse therapy and investigated their risk factors. Results: A total of 42 pediatric patients were enrolled in this study. The most frequently observed adverse effect was decreased heart rate (41/42), among whom 14 cases developed sinus bradycardia. Additionally, 33 patients exhibited elevated WBC count. Concurrent presentation of decreased heart rate and elevated WBC count was observed in 31 patients, while coexisting sinus bradycardia and elevated WBC count were documented in 13 patients. We did not observe other commonly reported adverse effects such as hypertension and electrolyte disturbances. The side effects of methylprednisolone pulse therapy (increased WBC count and reduced heart rate) both showed a positive correlation with patient age. Conclusions: The occurrence of bradycardia and leukocytosis is observed in pediatric patients following methylprednisolone pulse therapy for neurological diseases during hospitalization. These phenomena, being asymptomatic and frequently going unnoticed, generally require no specific treatment and allow for the continuation of the therapeutic course with vigilant monitoring. However, it is important to note that five patients still exhibited sinus bradycardia at discharge, and long‐term outcomes were not assessed in this study. Therefore, our conclusions regarding the safety of continuing pulse therapy are based solely on short‐term in‐hospital observations. Ambulatory ECG monitoring is recommended prior to high‐dose methylprednisolone pulse therapy. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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