Increasing Placebo Response Rates and the Threat to Clinical Trials: How Will We Identify Effective Treatments for Rheumatic Disorders?
The article discusses the increasing rates of placebo responses in clinical trials for psoriasis and psoriatic arthritis, particularly noting that these rates are higher in low-income countries compared to high-income countries. This trend complicates the ability to identify effective treatments, as...
| Publicado en: | Arthritis & Rheumatology Vol. 78; no. 1; pp. 1 - 4 |
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| Autores principales: | , , |
| Formato: | commentary editorial tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jan2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191211787&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191211787 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23265191 H06R jtl: Arthritis & Rheumatology issn: 23265191 maglogo: N pubinfo: dt: Jan2026 vid: 78 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 191211787 188171411 191211787 191211787 10.1002/art.43303 191211787 ppf: 1 ppct: 3 formats: tig: atl: Increasing Placebo Response Rates and the Threat to Clinical Trials: How Will We Identify Effective Treatments for Rheumatic Disorders? aug: au: Parkes, Matthew J. Felson, David T. LaValley, Michael P. affil: Centre for Biostatistics, Division of Population Health, Health Services Research & Primary Care, School of Health Sciences, University of Manchester and NIHR Manchester Biomedical Research Centre and NIHR HealthTech Research Centre in Emergency and Acute Care, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom sug: subj: Arthritis, Psoriatic Drug Therapy Psoriasis Drug Therapy Research Subject Recruitment Randomized Controlled Trials Socioeconomic Factors Placebos Drug Efficacy Low and Middle Income Countries Developed Countries Patient-Reported Outcomes Study Design ab: The article discusses the increasing rates of placebo responses in clinical trials for psoriasis and psoriatic arthritis, particularly noting that these rates are higher in low-income countries compared to high-income countries. This trend complicates the ability to identify effective treatments, as the active treatment response does not keep pace with placebo responses in psoriatic arthritis trials. The article also explores factors influencing placebo responses, such as patient expectations and the method of placebo administration, and suggests strategies to minimize these responses in trials. Additionally, it highlights emerging approaches like target trial emulation as alternatives to traditional randomized trials, aiming to address limitations in trial design and patient diversity. pubtype: Academic Journal doctype: commentary editorial tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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