A single dose of lamotrigine induces a positive memory bias in healthy volunteers.
Background Lamotrigine has been shown to be effective in the long-term treatment and relapse prevention of depression in bipolar disorder. However, the neuropsychological mechanisms underlying these effects are unclear. We investigated the effects of lamotrigine on a battery of emotional processing...
| Publicado en: | Psychological Medicine Vol. 55; pp. 1 - 8 |
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| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Cambridge University Press
2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191245158&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191245158 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00332917 6Q3 jtl: Psychological Medicine issn: 00332917 maglogo: N pubinfo: dt: 2025 vid: 55 pid: 15979 pub: Cambridge University Press artinfo: ui: 191245158 191245158 191245158 10.1017/S0033291725000777 191245158 ppf: 1 ppct: 7 formats: tig: atl: A single dose of lamotrigine induces a positive memory bias in healthy volunteers. aug: sug: subj: Lamotrigine Administration and Dosage Dose-Response Relationship, Drug Memory Drug Effects Drug Efficacy Evaluation Emotions Drug Effects Lamotrigine Pharmacodynamics Task Performance and Analysis Antidepressive Agents Cognition Drug Effects Human Randomized Controlled Trials Random Assignment Male Female Adult Funding Source Volunteer Workers Double-Blind Studies Placebos Administration and Dosage Affect Drug Effects Neuropsychological Tests Attention Drug Effects Bipolar Disorder Prevention and Control Depression Prevention and Control Visual Analog Scaling State-Trait Anxiety Inventory Psychological Tests Lamotrigine Adverse Effects Agitation Chemically Induced Xerostomia Chemically Induced Nausea Chemically Induced Aggression Chemically Induced Tremor Chemically Induced Headache Chemically Induced Dizziness Chemically Induced Back Pain Chemically Induced Arthralgia Chemically Induced Vision Disorders Chemically Induced Pruritus Chemically Induced Descriptive Statistics Data Analysis Software Analysis of Variance Paired T-Tests Prospective Studies Comparative Studies Pretest-Posttest Control Group Design Adult: 19-44 years Male Female ab: Background Lamotrigine has been shown to be effective in the long-term treatment and relapse prevention of depression in bipolar disorder. However, the neuropsychological mechanisms underlying these effects are unclear. We investigated the effects of lamotrigine on a battery of emotional processing tasks in healthy volunteers, previously shown to be sensitive to antidepressant drug action in similar experimental designs. Methods Healthy volunteers (n = 36) were randomized in a double-blind design to receive a single dose of placebo or 300 mg lamotrigine. Mood and subjective effects were monitored throughout the study period, and emotional processing was assessed using the Oxford Emotional Test Battery (ETB) 3 hours post-administration. Results Participants receiving lamotrigine showed increased accurate recall of positive versus negative self-descriptors, compared to those in the placebo group. There were no other significant effects on emotional processing in the ETB, and lamotrigine did not affect ratings of mood or subjective experience. Conclusions Lamotrigine did not induce widespread changes in emotional processing. However, there was increased positive bias in emotional memory, similar to the effects of antidepressants reported in previous studies. Further work is needed to assess whether similar effects are seen in the clinical treatment of patients with bipolar disorder and the extent to which this is associated with its clinical action in relapse prevention. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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