Altered morphological cortical thickness and disrupted network attributes and its relationships with drug use characteristics and impulsivity in abstinent male subjects with methamphetamine use disorder.
Background Methamphetamine (METH) dependence is a globally significant public health concern with no efficacious treatment. Trait impulsivity is associated with the initiation, maintenance, and recurrence of substance abuse. However, the presence of these associations in METH addiction, as well as t...
| Published in: | Psychological Medicine Vol. 55; pp. 1 - 11 |
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| Format: | pictorial research tables/charts Journal Article |
| Published: |
Cambridge University Press
2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191245180&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191245180 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00332917 6Q3 jtl: Psychological Medicine issn: 00332917 maglogo: N pubinfo: dt: 2025 vid: 55 pid: 15979 pub: Cambridge University Press artinfo: ui: 191245180 191245180 191245180 10.1017/S0033291725101165 191245180 ppf: 1 ppct: 10 formats: tig: atl: Altered morphological cortical thickness and disrupted network attributes and its relationships with drug use characteristics and impulsivity in abstinent male subjects with methamphetamine use disorder. aug: sug: subj: Cerebral Cortex Pathology Substance Use Disorders Methamphetamine Adverse Effects Impulsive Behavior Brain Cortical Thickness Neural Pathways Human Male Nervous System T-Tests Chi Square Test Post Hoc Analysis Data Analysis Software Funding Source Confidence Intervals Male ab: Background Methamphetamine (METH) dependence is a globally significant public health concern with no efficacious treatment. Trait impulsivity is associated with the initiation, maintenance, and recurrence of substance abuse. However, the presence of these associations in METH addiction, as well as the underlying neurobiological mechanisms, remains incompletely understood. Methods We scanned 110 individuals with METH use disorder (MUDs) and 55 matched healthy controls (HCs) using T1-weighted imaging and assessed their drug use characteristics and trait impulsivity. Surface-based morphometry and graph theoretical analysis were used to investigate group differences in brain morphometry and network attributes. Partial correlations were conducted to investigate the relationships between brain morphometric changes, drug use parameters, and trait impulsivity. Mediation analyses examined how trait impulsivity and drug craving influenced the link between brain morphometric change and MUD severity in patients. Results MUDs exhibited thinner thickness in the left fusiform gyrus and right pars opercularis, as well as diminished small-world properties in their structural covariance networks (SCNs) compared to HCs. Furthermore, reduced cortical thickness in the right pars opercularis was linked to motor impulsivity (MI) and MUD severity, and the association between the right pars opercularis thickness and MUD severity was significantly mediated by both MI and cue-induced craving. Conclusions These findings suggest that MUDs exhibit distinct brain structural abnormalities in both the cortical thickness and SCNs and highlight the critical role of impulse control in METH addiction. This insight may offer a potential neurobiological target for developing therapeutic interventions to treat addiction and prevent relapse. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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