Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task.
Background According to the aberrant salience proposal, reward processing abnormality, specifically erroneous reward prediction error (RPE) signaling due to stimulus-independent release of dopamine, underlies delusions in schizophrenia. However, no studies to date have examined RPE-associated brain...
| Publicado en: | Psychological Medicine Vol. 55; pp. 1 - 11 |
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| Formato: | diagnostic images equations & formulas research tables/charts Journal Article |
| Publicado: |
Cambridge University Press
2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191245184&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191245184 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00332917 6Q3 jtl: Psychological Medicine issn: 00332917 maglogo: N pubinfo: dt: 2025 vid: 55 pid: 15979 pub: Cambridge University Press artinfo: ui: 191245184 191245184 191245184 10.1017/S0033291724003258 191245184 ppf: 1 ppct: 10 formats: tig: atl: Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task. aug: sug: subj: Delusions Risk Factors Reward Magnetic Resonance Imaging Task Performance and Analysis Schizophrenia Risk Assessment Human Cross Sectional Studies Spain DSM Severity of Illness Basal Ganglia Thalamus Scales Prefrontal Cortex Hippocampus Adult Adolescence Middle Age Aged Male Female Feedback Learning Methods Descriptive Statistics Kruskal-Wallis Test T-Tests Data Analysis Software Funding Source Adult: 19-44 years Adolescent: 13-18 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background According to the aberrant salience proposal, reward processing abnormality, specifically erroneous reward prediction error (RPE) signaling due to stimulus-independent release of dopamine, underlies delusions in schizophrenia. However, no studies to date have examined RPE-associated brain activations in relation to this symptom. Methods Seventy-eight patients with a DSM-5 diagnosis of schizophrenia/schizoaffective disorder and 43 healthy individuals underwent fMRI while they performed a probabilistic monetary reward task designed to generate a measure of RPE. Ratings of delusions and referentiality were made in the patients. Results Using whole-brain, voxel-based analysis, schizophrenia patients showed only minor differences in RPE-associated activation compared to healthy controls. Within the patient group, however, severity of delusions was inversely associated with RPE-associated activation in areas including the caudate nucleus, the thalamus and the left pallidum, as well as the lateral frontal cortex bilaterally, the pre- and postcentral gyrus and supplementary motor area, the middle cingulate gyrus, and parts of the temporal and parietal cortex. A broadly similar pattern of association was seen for referentiality. Conclusions According to this study, while patients with schizophrenia as a group do not show marked alterations in RPE signaling, delusions and referentiality are associated with reduced activation in parts of the prefrontal cortex and the basal ganglia, though not specifically the ventral striatum. The direction of the changes is on the face of it contrary to that predicted by aberrant salience theory. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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