Associations between early life adversity and the development of gray matter macrostructure and microstructure.
Background Early life adversity (ELA) is common and cross-sectionally associated with brain gray matter structure, including cortical thickness, cortical surface area, and subcortical volumes in childhood. However, to which degree ELA influences the trajectory of gray matter macrostructural and micr...
| Publicado en: | Psychological Medicine Vol. 55; pp. 1 - 12 |
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| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Cambridge University Press
2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191245191&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191245191 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00332917 6Q3 jtl: Psychological Medicine issn: 00332917 maglogo: N pubinfo: dt: 2025 vid: 55 pid: 15979 pub: Cambridge University Press artinfo: ui: 191245191 191245191 191245191 10.1017/S0033291725102651 191245191 ppf: 1 ppct: 11 formats: tig: atl: Associations between early life adversity and the development of gray matter macrostructure and microstructure. aug: sug: subj: Adverse Childhood Experiences Complications Gray Matter Pathology Gray Matter Physiopathology Hardiness Stress Disorders, Post-Traumatic Physiopathology Brain Physiopathology Neurodegenerative Diseases Physiopathology Human Male Female Child Adolescence Funding Source Prospective Studies United States Quality of Health Care Cross Sectional Studies Magnetic Resonance Imaging Questionnaires Descriptive Statistics Comparative Studies Multiple Linear Regression Data Analysis Software Pearson's Correlation Coefficient Sociodemographic Factors Brain Mapping Methods Risk Assessment Internalizing Behavior Risk Factors Mental Disorders Risk Factors Child: 6-12 years Adolescent: 13-18 years Male Female ab: Background Early life adversity (ELA) is common and cross-sectionally associated with brain gray matter structure, including cortical thickness, cortical surface area, and subcortical volumes in childhood. However, to which degree ELA influences the trajectory of gray matter macrostructural and microstructural development during childhood and adolescence remains largely unexplored. Methods We included 6414 participants from the Adolescent Brain Cognitive Development study at ages 9–11, where 1923 were followed to ages 11–13. We used linear mixed-effects models to test for associations between MRI-derived longitudinal measures of gray matter macro- (cortical thickness, surface area, subcortical volume) or microstructure (T1w/T2w ratio) and trauma exposure, parental acceptance, household abuse, and being resilient or susceptible to trauma in terms of developing an internalizing disorder. Results At ages 9–11, higher levels of parental acceptance, trauma exposure, and being trauma resilient were associated with lower levels of cortical thickness. In contrast, being trauma susceptible was negatively related to hippocampal volume and cortical surface area. Longitudinally, more parental acceptance at baseline was associated with more cortical thinning between ages 9–11 and 11–13, while more household abuse was associated with less change in T1w/T2w ratio over time. Conclusions Parental acceptance and trauma resilience are linked to accelerated pace of apparent cortical thinning in youth aged 9–13 years, while household abuse is associated with slower microstructural development, as reflected by smaller longitudinal changes in the T1w/T2w ratio. Threat and deprivation may be distinctly associated with gray matter developmental trajectories in late childhood. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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