Multimodal prediction of psychotic-like experiences using elastic net modeling: external validation in a clinical sample.
Background Psychotic-like experiences (PLEs) are considered a subclinical component of psychosis continuum. Studies indicate that PLEs arise from multimodal factors, yet research comprehensively examining these factors together remains scarce. Using a large youth sample, we present the first model t...
| Publicado en: | Psychological Medicine Vol. 55; pp. 1 - 11 |
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| Formato: | research tables/charts Journal Article |
| Publicado: |
Cambridge University Press
2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191245382&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191245382 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00332917 6Q3 jtl: Psychological Medicine issn: 00332917 maglogo: N pubinfo: dt: 2025 vid: 55 pid: 15979 pub: Cambridge University Press artinfo: ui: 191245382 191245382 191245382 10.1017/S0033291725102201 191245382 ppf: 1 ppct: 10 formats: tig: atl: Multimodal prediction of psychotic-like experiences using elastic net modeling: external validation in a clinical sample. aug: sug: subj: Psychotic Disorders Physiopathology Psychotic Disorders Diagnosis Psychotic Disorders Symptoms Patient Attitudes Brain Radiography Brain Mapping Human Funding Source Turkiye Male Female Adolescence Young Adult Machine Learning Magnetic Resonance Imaging Brain Physiology Cognition Self Concept Environmental Exposure Prediction Models Predictive Value of Tests Hardiness Neuroradiography Psychotic Disorders Familial and Genetic Family History Scales Descriptive Statistics Data Analysis Software Chi Square Test Structural Equation Modeling Time Series Univariate Statistics Models, Statistical Social Cohesion ROC Curve Interpersonal Relations Sibling Relations Sensitivity and Specificity Confidence Intervals Adolescent: 13-18 years Male Female ab: Background Psychotic-like experiences (PLEs) are considered a subclinical component of psychosis continuum. Studies indicate that PLEs arise from multimodal factors, yet research comprehensively examining these factors together remains scarce. Using a large youth sample, we present the first model that simultaneously examines multimodal factors related to PLEs. As a secondary aim, we evaluate the model's ability to explain psychosis in an external validation cohort that included individuals experiencing psychosis. Methods After applying variable selection including generalized estimating equations, correlation filtering, Least Absolute Shrinkage and Selection Operator model to 741 variables (i.e. environmental factors, cognitive appraisals, clinical variables, cognitive functioning, and structural brain connectome measures), obtained PLEs predictors (N = 27) and covariates (i.e. age, sex, IQ) were included in the classification model based on Elastic Net algorithm for predicting high/low PLEs in 396 healthy participants aged 14–24 (M age = 19.72 ± 2.5). We externally validated PLE-related predictors in a clinical sample comprising first-episode psychosis patients (n = 19), their siblings (n = 20), and healthy controls (n = 19). Results Eleven factors, including environmental and cognitive appraisals, along with 16 structural network properties spanning frontal, temporal, occipital, and parietal regions, were identified as important predictors of PLEs. The model's performance was moderate in predicting low versus high PLEs (accuracy = 75%, AUC = 0.750). Specificity was high (84.2%) in distinguishing siblings from patients. Conclusions Multimodal features, including environmental burden, cognitive schemas, and brain network alterations, predict PLEs and partially generalize to clinical psychosis. These variables may reflect intermediate phenotypes across the psychosis spectrum, offering insights into both vulnerability and resilience. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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